Best Vitamin B6 Supplements 2026: Cost per Effective Dose
Top pick for Vitamin B6: Nutricost Vitamin B6 (Pyridoxine HCl) 25 mg (240 Capsules) — 25mg B6 per 1 capsule, $0.05/day.
All Vitamin B6 Supplements Compared
All 12 products sorted by cost per labelled serving (lowest first). Dose, certification, and pricing verified against NIH DSLD and manufacturer data.
Read the dose column before the price column. Servings in this category are not equivalent — they range from 25 to 100 mg B6 per serving. A lower cost per day here can simply mean a smaller serving, so the cheapest row is not automatically the best value.
| Product | Brand | Dose / Serving | Cost / Day | Certification | Pick | Buy |
|---|---|---|---|---|---|---|
| Nutricost Vitamin B6 (Pyridoxine HCl) 25 mg (240 Capsules) | Nutricost | 25mg B6 / 1 capsule | $0.05 | None | Buy | |
| Nutricost Vitamin B6 (Pyridoxine HCl) 100 mg (240 Capsules) | Nutricost | 100mg B6 / 1 capsule | $0.05 | None | Buy | |
| NOW Vitamin B-6 (Pyridoxine HCl) 100 mg (250 Capsules) | NOW Foods | 100mg B6 / 1 capsule | $0.05 | None | Buy | |
| Solgar Vitamin B6 25 mg (100 Tablets) | Solgar | 25mg B6 / 1 tablet | $0.06 | None | Buy | |
| Nature's Bounty Vitamin B6 100 mg (100 Tablets) | Nature's Bounty | 100mg B6 / 1 tablet | $0.06 | None | Buy | |
| Nutricost P5P Vitamin B6 50 mg (240 Capsules) | Nutricost | 50mg B6 / 1 capsule | $0.07 | None | Buy | |
| Nature Made Vitamin B6 100 mg (100 Tablets, USP) | Nature Made | 100mg B6 / 1 tablet | $0.11 | USP Verified | Buy | |
| NOW P-5-P 50 mg with Magnesium (90 Capsules) | NOW Foods | 33mg B6 / 1 capsule | $0.14 | None | Buy | |
| Country Life P-5-P 50 mg (100 Tablets) | Country Life | 34mg B6 / 1 tablet | $0.15 | None | Buy | |
| Life Extension Pyridoxal 5'-Phosphate 100 mg (60 Capsules) | Life Extension | 100mg B6 / 1 capsule | $0.28 | None | Buy | |
| Pure Encapsulations P5P 50 (180 Capsules) | Pure Encapsulations | 50mg B6 / 1 capsule | $0.29 | None | Buy | |
| Thorne Pyridoxal 5'-Phosphate (180 Capsules) | Thorne | 34mg B6 / 1 capsule | $0.31 | None | Buy |
In-Depth Vitamin B6 Guides
Go deeper on vitamin b6 — by goal, by form, and what the evidence actually supports:
Our Picks
Lowest Cost: Nutricost Vitamin B6 (Pyridoxine HCl) 25 mg (240 Capsules)
25mg B6 per 1 capsule. $0.05/day. 240 servings per container at $11.95.
Nutricost Vitamin B6 (Pyridoxine HCl) 25 mg (240 Capsules) →
How We Rank Vitamin B6 Supplements
Every product is evaluated on three criteria:
- Cost per day. Not cost per pill or cost per bottle — what it actually costs per day at the product's labelled serving. Where a category's servings differ in strength we flag it above the table, because cost per day is only comparable when the doses are.
- Third-party certification. USP Verified, NSF Certified for Sport, and ConsumerLab Approved indicate independent testing for purity, potency, and contaminants.
- Bioavailable form. We prioritize products using the specific chemical form shown to be most effective in published research.
Rankings are not influenced by affiliate commissions. We earn the same commission regardless of which product you choose. Read our full methodology.
Personalize Your Vitamin B6 Choice
Not sure which vitamin b6 supplement is right for you? Use our free tools:
- DNA Supplement Analyzer — upload 23andMe or AncestryDNA data to check for genetic variants affecting vitamin b6 metabolism. Runs entirely in your browser.
- Lab Results Interpreter — enter your blood test values to get personalized dosing recommendations.
- Supplement Stack Builder — build a complete protocol based on your age, sex, medications, and goals.
- Supplement Audit — already taking vitamin b6? Check if you have the right form and dose.