GLP-1 Supplement Calculator: Personalized Protocol for Ozempic, Wegovy & Mounjaro
Get a personalized GLP-1 supplement protocol in 60 seconds. Enter your drug, dose, symptoms, and current supplements below. The calculator identifies your specific nutrient gaps, priority-ranks what you need, excludes what you already take, and shows the total cost for just the missing supplements. Based on clinical evidence from a retrospective study of 461,382 GLP-1 users (PMID: 40584822) and the joint advisory from ACLM, ASN, OMA, and TOS (PMID: 40445127).
Your GLP-1 Profile
How the Calculator Works
This calculator uses clinical data from peer-reviewed studies to estimate your supplement needs:
- Lean mass loss estimate: Based on the finding that 25-40% of weight lost on GLP-1 drugs is lean mass (PMID: 39431379), adjusted for your resistance training status
- Protein target: Calculated at 1.2-1.6g/kg/day per the joint advisory from ACLM, ASN, OMA, and TOS (PMID: 40445127)
- Nutrient gap identification: Based on depletion data from a retrospective study of 461,382 GLP-1 users (PMID: 40584822)
- Symptom matching: Hair loss, cramps, and nausea trigger specific supplement recommendations based on known nutrient causes
- Drug-specific adjustments: Tirzepatide produces greater weight loss (up to 22.5% vs 15-17%), requiring more aggressive supplementation (PMID: 39719170)
Frequently Asked Questions
What supplements do I need on my specific GLP-1 drug?
The core supplements are the same across semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound): protein, multivitamin, magnesium, biotin, and collagen. However, tirzepatide users may need more aggressive protein supplementation due to greater weight loss (up to 22.5% vs 15-17%). Use the calculator above to get a personalized protocol based on your specific drug, dose, and symptoms.
How much do GLP-1 supplements cost per month?
The total cost depends on which supplements you need. Essential tier (multivitamin + magnesium + vitamin D) costs about $1.17/day ($35/month). With protein and biotin added, $2.26/day ($68/month). The comprehensive stack with collagen and electrolytes runs $3.11/day ($93/month). The calculator shows only what you are missing, so if you already take some supplements, your cost will be lower.
Should I change my supplements based on my GLP-1 dose?
Higher doses generally suppress appetite more aggressively, meaning greater caloric reduction and higher risk of nutrient depletion. At maintenance doses (Ozempic 1.0-2.0mg, Mounjaro 10-15mg), protein supplementation becomes especially critical because weight loss is most rapid.
Do I need different supplements for Mounjaro vs Ozempic?
The supplement categories are the same, but tirzepatide (Mounjaro/Zepbound) produces greater weight loss (up to 22.5% vs 15-17%), which means proportionally greater nutrient depletion and lean mass loss (PMID: 39719170). The calculator adjusts protein recommendations and priority rankings based on your drug.
What bloodwork should I get on GLP-1 drugs?
Request at baseline and every 6 months: 25-hydroxyvitamin D, vitamin B12, ferritin (not just hemoglobin), iron panel, CBC, CMP, RBC magnesium (not serum magnesium), zinc, folate, and HbA1c. The joint advisory from four major medical societies recommends monitoring for nutritional risks (PMID: 40445127).
Sources
- Butsch WS, et al. "Nutritional deficiencies in GLP-1 RA users: retrospective cohort of 461,382 patients." Obesity Pillars. 2025. PMID: 40584822
- Mozaffarian D, et al. "Nutritional Priorities to Support GLP-1 Therapy: Joint Advisory from ACLM, ASN, OMA, and TOS." Obesity. 2025. PMID: 40445127
- "Characterizing body composition modifying effects of GLP-1 RAs: A meta-analysis." 2024. PMID: 39431379
- "Effect of GLP-1 RAs on body composition: Systematic review and network meta-analysis." 2024. PMID: 39719170
- "Semaglutide and Accelerated Sarcopenia in Older Adults." 2025. PMID: 40631351
- "Micronutrient Deficiencies Associated With GLP-1 RA Therapy: A Narrative Review." 2025. PMID: 41549912