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Best Vitamin K2 Supplement (2026): MK-7 Picks, Ranked

By Erin Rose · Updated · Methodology · About Us

Also searched: best vitamin K2 supplement, best MK-7 supplement, best K2 with D3.

Best overall: NOW Foods MK-7 100 mcg at $0.22/day — branded MenaQ7 (all-trans, soy-free), the trial-grade ingredient at the standard 100 mcg dose.

Best value: Nutricost MK-7 100 mcg at $0.07/day — same dose, lowest cost.

Best D3 + K2 combo: Sports Research D3 + K2 — 5,000 IU D3 with 100 mcg MK-7 in one softgel (see taking vitamin D with K2).

One note on verification: unlike melatonin, K2 products rarely carry a USP or NSF label-accuracy mark — so we weight the quality signals that do exist for K2: all-trans content and a branded, tested ingredient like MenaQ7.

Informational summary of published research — not medical advice. If you take warfarin or another vitamin K antagonist, do not start K2 without your physician. As an Amazon Associate we earn from qualifying purchases; picks are ranked by form quality and cost per day, never commissions.

Our Top Picks at a Glance

Best vitamin K2 supplements ranked by form quality and cost per day
Award Product Form K2 Dose Why this one Cost/Day Buy
Best Overall NOW Foods MK-7 Vitamin K2 100 mcg MK-7 (all-trans) 100 mcg Branded MenaQ7 — the all-trans, soy-free ingredient used in the clinical trials, at the standard dose. $0.22 Check price →
Best Value Nutricost Vitamin K2 MK-7 100 mcg MK-7 100 mcg The same 100 mcg MK-7 dose at the lowest cost per day — a full year in one bottle. $0.07 Check price →
Best D3 + K2 Sports Research Vitamin D3 + K2 D3 + MK-7 5,000 IU + 100 mcg Vegan D3 and MK-7 in one softgel — the pairing in a single daily pill. $0.57 Check price →
Most Complete Life Extension Super K K1 + MK-4 + MK-7 1,180 mcg K2 Adds K1 and a little MK-4 on top of an effective MK-7 dose — it complements MK-7, it doesn't replace it. $0.25 Check price →
Higher Dose NOW Foods Vitamin K2 (MK-7) 300 mcg MK-7 (all-trans) 300 mcg Only worth the extra cost for the upper end of the studied 90–200 mcg range, or to split a bottle. $0.31 Check price →

Why MK-7 — and why "all-trans" matters

Almost every K2 buying decision comes down to one thing: choose MK-7, not MK-4. MK-7 has a long half-life, so a single 90–200 mcg daily dose reaches and holds useful blood levels; MK-4 is cleared within hours and only worked in trials at a pharmaceutical 45 mg a day (taken as 15 mg three times daily). That's why the standalone supplements worth buying are MK-7. For the full pharmacology, see MK-7 vs MK-4.

The quality wrinkle is that MK-7 comes in an active all-trans form and a much less active cis form that contaminates cheap synthetic material. Branded, fermentation-derived ingredients like MenaQ7 are tested to guarantee all-trans content — which is why our top pick uses one. A label that says "all-trans" or names its ingredient brand is a genuine quality signal; a bargain MK-7 with neither is a gamble.

What to look for

  1. MK-7, not MK-4 — the practical form for daily supplementation.
  2. All-trans, ideally branded — look for "all-trans" or a named ingredient (MenaQ7). This is the single biggest quality differentiator.
  3. A trial-anchored dose — 90–200 mcg MK-7. 100 mcg is the sweet spot; 300 mcg sits at the upper studied range.
  4. Soy-free if you're allergic — natto-derived MK-7 can carry trace soy; chickpea-fermented options (like our top pick) avoid it.
  5. Pure MK-7 vs a blend — a standalone MK-7 is cleanest. Some products (like Life Extension Super K) add K1 — the form in leafy greens your liver uses for blood clotting — plus a little MK-4 on top; that's fine if you want fuller vitamin-K coverage, but the MK-7 is what does the bone-and-artery work. A D3+K2 combo is also fine if it fits your routine.

What we don't recommend

  • Unbranded bargain MK-7 with no all-trans claim — you can't tell how much is the inactive cis form.
  • Low-dose MK-4-only products — MK-4 doesn't accumulate at supplement doses; you'd need a pharmaceutical 45 mg regimen for the effect its trials showed.
  • Anything promising to "clean out" or "reverse" arterial calcification — the recent hard-endpoint trials were negative. K2 supports the calcium-routing system; it doesn't dissolve existing plaque. See the honest evidence on the MK-7 vs MK-4 page.
  • Starting K2 while on warfarin without your doctor — vitamin K opposes warfarin, and consistency of intake matters. This is a conversation with your prescriber, not a self-serve add-on.

Frequently Asked Questions

What is the best vitamin K2 supplement?

For most people the best vitamin K2 is a standalone all-trans MK-7 at the clinical 100 mcg dose. Our top pick is NOW Foods MK-7 100 mcg, which uses the branded MenaQ7 ingredient (all-trans, soy-free) at about $0.22 a day. For the lowest cost, Nutricost MK-7 100 mcg is about $0.07 a day. If you want vitamin D in the same pill, Sports Research D3 + K2 pairs 5,000 IU of D3 with 100 mcg of MK-7. Choose MK-7 over MK-4, and look for an all-trans label.

Should I take a D3 and K2 combo or separate supplements?

Either works. A combo is convenient and reflects the mechanistic pairing (vitamin D raises calcium absorption; K2 helps route that calcium into bone). But the "45 mcg K2 per 1,000 IU D3" ratio printed on combos is a formulation convention, not a validated dose — so a combo is not medically superior to taking a 90–200 mcg MK-7 separately. Pick a combo for convenience, or separate products if you want to control each dose independently.

How much vitamin K2 should I take per day?

A trial-anchored MK-7 dose is 90–200 mcg per day; the 3-year trials used 180 mcg. There is no established upper limit for vitamin K. Take it with a fatty meal. The one hard rule: if you take warfarin or another vitamin K antagonist, do not start K2 without your physician. See our MK-7 vs MK-4 guide for the full dosing breakdown.

What does "all-trans" MK-7 mean on a label?

MK-7 exists as an active all-trans form and a much less active cis form that can contaminate cheap synthetic material. All-trans is the form used in the clinical trials and the one you want. Branded, fermentation-derived ingredients like MenaQ7 are tested to guarantee all-trans content; a label that says "all-trans" or names a branded ingredient is a good quality signal.

Related Guides

Sources

  1. Sato T, et al. "Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women." Nutr J. 2012;11:93. PMID: 23140417
  2. Schurgers LJ, et al. "Vitamin K-containing dietary supplements: synthetic K1 vs natto-derived MK-7." Blood. 2007;109(8):3279-83. PMID: 17158229
  3. Knapen MHJ, et al. "Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women." Osteoporos Int. 2013;24(9):2499-507. PMID: 23525894
  4. Cirilli I, et al. "Carboxylative efficacy of trans and cis MK7." Biofactors. 2022;48(5):1058-1066. PMID: 35583412
  5. NIH Office of Dietary Supplements. "Vitamin K: Fact Sheet for Health Professionals." ods.od.nih.gov