Best Methylfolate Supplements (2026) — Ranked by Cost per Effective Dose
Top pick for Methylfolate: Jarrow Formulas Methyl Folate 400 mcg — 400mcg per 1 capsule, $0.17/day. Our best-value pick.
All Methylfolate Supplements Compared
All 3 products sorted by cost per clinically-effective daily dose (lowest first). Dose, certification, and pricing verified against NIH DSLD and manufacturer data.
| Product | Brand | Dose / Serving | Cost / Day | Certification | Pick | Buy |
|---|---|---|---|---|---|---|
| Life Extension Optimized Folate (L-Methylfolate) 1700 mcg | Life Extension | 1700mcg / 1 tablet | $0.15 | None | Budget Pick | Buy |
| Jarrow Formulas Methyl Folate 400 mcg | Jarrow Formulas | 400mcg / 1 capsule | $0.17 | None | Best Value | Buy |
| Thorne 5-MTHF (Methylfolate) 1 mg | Thorne | 1000mcg / 1 capsule | $0.35 | NSF Certified for Sport | Quality Pick | Buy |
Our Picks
Best Value: Jarrow Formulas Methyl Folate 400 mcg
400mcg per 1 capsule. $0.17/day. 60 servings per container at $10.49.
Quality Pick: Thorne 5-MTHF (Methylfolate) 1 mg
1000mcg per 1 capsule. NSF Certified for Sport. $0.35/day. 60 servings per container at $21.00.
Budget Pick: Life Extension Optimized Folate (L-Methylfolate) 1700 mcg
1700mcg per 1 tablet. $0.15/day. 100 servings per container at $15.00.
How We Rank Methylfolate Supplements
Every product is evaluated on three criteria:
- Cost per clinically-effective daily dose. Not cost per pill or cost per bottle. We calculate what it actually costs per day to take the dose used in clinical trials.
- Third-party certification. USP Verified, NSF Certified for Sport, and ConsumerLab Approved indicate independent testing for purity, potency, and contaminants.
- Bioavailable form. We prioritize products using the specific chemical form shown to be most effective in published research.
Rankings are not influenced by affiliate commissions. We earn the same commission regardless of which product you choose. Read our full methodology.
Personalize Your Methylfolate Choice
Not sure which methylfolate supplement is right for you? Use our free tools:
- DNA Supplement Analyzer — upload 23andMe or AncestryDNA data to check for genetic variants affecting methylfolate metabolism. Runs entirely in your browser.
- Lab Results Interpreter — enter your blood test values to get personalized dosing recommendations.
- Supplement Stack Builder — build a complete protocol based on your age, sex, medications, and goals.
- Supplement Audit — already taking methylfolate? Check if you have the right form and dose.