Vitamin D3 5000 IU with K2: Which Bottles Have Real MK-7
Not medical advice. This summarizes the vitamin K2 trials, the vitamin D dosing limits, the labels manufacturers file with the NIH, and current Amazon prices. 5,000 IU is a correction dose: test first. K2 interacts with warfarin; do not add it to a blood thinner without your prescriber.
Quick answer
A real K2 dose is 90–200 mcg of MK-7, named as MK-7, and most 5,000 IU bottles do not carry one at all. Of the 95 5,000 IU vitamin D labels filed with the NIH that we read in full, only 15.8% pair K2. On the standalone K2 shelf, the median label sells 100 mcg, 63.6% sit inside the 90–200 mcg range the three-year trials used, 72.5% name MK-7 and 22.3% name no form.
Buy the combo only if you want K2 anyway; if you do, buy one that prints the MK-7 microgram figure. The cheapest 5,000 IU + K2 we track is Horbäach Vitamin D3 5000 IU + K2 MK-7 100 mcg at $0.055 a day (100 mcg MK-7); the USP Verified one is Nature Made Vitamin D3 5000 IU + K2 100 mcg at $0.419; two separate bottles cost $0.103. See every 5,000 IU + K2 bottle ranked →
Not sure you need the K2? Start with vitamin D with or without K2; not sure about 5,000, with the 5,000 IU page →
Every 5,000 IU + K2 we track, with its MK-7 dose, ranked by cost
Product links go to Amazon and we may earn a commission if you buy. It never changes which product we pick or what we say about it. How we choose.
One softgel or capsule is one 5,000 IU dose on every product here, so cost per dose is the pack price divided by the count. The K2 column is that bottle’s microgram figure and form, with where we read it (the Amazon listing on the price date, or its NIH label by id); “in range” means 90–200 mcg of MK-7. Cheapest first; prices are the current Amazon price for the exact pack.
| Product | Per dose | Per year | K2 per serving | Read from | In range | Count | Price | Verification | Buy |
|---|---|---|---|---|---|---|---|---|---|
 Horbäach Vitamin D3 5000 IU + K2 MK-7 100 mcg | $0.055 | $20 | 100 mcg MK-7 | Amazon listing title, 2026-09-21 | yes | 180 | $9.88 | none stated | Check price |
 Micro Ingredients Vitamin D3 5,000 IU + K2 MK-7 100 mcg | $0.100 | $36 | 100 mcg MK-7 | NIH DSLD label 232088 | yes | 300 | $29.95 | none stated | Check price |
 Nutricost Vitamin D3 5000 IU + K2 100 mcg MK-7 | $0.125 | $45 | 100 mcg MK-7 | Amazon listing title, 2026-09-21 | yes | 120 | $14.95 | none stated | Check price |
 NOW Mega D-3 & MK-7 5,000 IU / 180 mcg | $0.199 | $73 | 180 mcg MK-7 (MenaQ7) | Amazon listing title, 2026-09-21 | yes | 120 | $23.89 | NPA GMP Certified | Check price |
 Sports Research Vitamin D3 + K2 | $0.319 | $116 | 100 mcg MK-7 | Amazon listing features, 2026-09-21 | yes | 120 | $38.30 | Non-GMO Verified, Vegan | Check price |
 Nature Made Vitamin D3 5000 IU + K2 100 mcg | $0.419 | $153 | 100 mcg MK-7 (all-trans) | NIH DSLD label 285746 | yes | 30 | $12.58 | USP Verified | Check price |
The spread is $0.055 to $0.419 a dose, 7.6× from cheapest to priciest, for the same 5,000 IU and, on 5 of 6 bottles, the same 100 mcg of MK-7; NOW Mega D-3 & MK-7 5,000 IU / 180 mcg carries 180 mcg, the trial dose. 1 of the 6 carries a USP Verified mark. For comparison, the cheapest plain 5,000 IU we track (Viva Naturals Vitamin D3 5000 IU, $0.028) plus the cheapest standalone 100 mcg MK-7 (Nutricost Vitamin K2 MK-7 100 mcg, $0.075) comes to $0.103 a day.
What K2 adds to 5,000 IU, and what the trials actually tested
The case for pairing is mechanistic: vitamin D increases calcium absorption and the production of vitamin K-dependent proteins, which need vitamin K to be activated (van Ballegooijen 2017, PMID 29138634). The K2 evidence on its own is real at one dose. In 244 healthy postmenopausal women, 180 mcg of MK-7 a day for 3 years improved vitamin K status and slowed the age-related loss of bone mineral density and strength at the spine and femoral neck (Knapen 2013, PMID 23525894), and in the same trial improved arterial stiffness and cut inactive matrix Gla protein by 50% against placebo (Knapen 2015, PMID 25694037). Combined D-plus-K trials, pooled across 8 randomized trials and 971 people, raised total bone density by a small pooled effect of 0.316 and lowered undercarboxylated osteocalcin (Kuang 2020, PMID 32219282). None of those trials used a 5,000 IU softgel, and none tested whether K2 prevents anything that 5,000 IU alone causes.
The form matters because the dose does. MK-7 and K1 are both absorbed well, peaking about 4 hours after a dose, but MK-7’s much longer half-life means it accumulates to 7- to 8-fold higher serum levels with daily intake and carboxylates osteocalcin more completely; the same paper warns that 50 mcg a day or more of MK-7 can interfere with warfarin (Schurgers 2007, PMID 17158229). MK-4 clears in hours, and its trials used 45,000 mcg a day, a pharmaceutical dose no combination softgel carries. So “with K2” on a 5,000 IU bottle means something only when the label says MK-7 and prints a figure in the 90–200 mcg range. The vitamin D side is unchanged by the K2: 5,000 IU raises 25(OH)D by roughly 35 ng/mL at equilibrium (Heaney 2003, PMID 12499343), sits above the Institute of Medicine’s 4,000 IU limit (Ross 2011, PMID 21118827), and the largest prevention trial gave 25,871 adults 2,000 IU and found no reduction in cancer or cardiovascular events (Manson 2019, PMID 30415629).
Who a 5,000 IU + K2 combo is for
The combo is for someone who has a reason for 5,000 IU and a reason for K2, and wants one softgel. The 5,000 IU reasons are a measured 25(OH)D below 20 ng/mL, obesity, malabsorption, little sun or age over 65, all on the 5,000 IU page. The K2 reasons are postmenopausal bone loss and arterial stiffness, where the 180 mcg MK-7 trials are the evidence. If both apply, a bottle at 100–180 mcg of MK-7 covers the K2 at the studied range and the 5,000 IU corrects the D, and the cheapest combos cost less than two bottles.
The combo is not for anyone on warfarin, and not a maintenance product. Every bottle here supplies at least the 50 mcg of MK-7 that the pharmacology paper flags as clinically relevant to oral anticoagulants, so anyone on a vitamin K antagonist should use plain vitamin D and talk to their prescriber (the warfarin guide has the detail). Once a retest shows an adequate level, step down to a 2,000 IU product plus a standalone K2 if you still want it.
We read 95 5,000 IU labels and 327 K2 labels: pairing is rare, and a real dose is rarer
Original researchFrom 948 vitamin D labels retrieved from the NIH Dietary Supplement Label Database on 2026-08-27, the 95 labels at exactly 5,000 IU were read in full on 2026-09-18 for K2 pairing, verification and directions. Separately, 892 vitamin K2 labels were read, 551 blends excluded, and the 327 standalone K2 products classified by form and by dose against the 90–200 mcg trial range. Every figure printed as a finding held in both halves of its census.
15.8% of the 95 5,000 IU labels pair K2, and 13.7% carry a USP statement. On the standalone K2 shelf, the median label sells 100 mcg; 75.8% are at or above the 90 mcg floor and 63.6% are inside 90–200 mcg. 72.5% name MK-7, 4.3% name MK-4 and 22.3% name no form, and an unnamed menaquinone could be MK-4 at a dose that clears in hours. Of the 6 combination bottles on this page, all 6 name MK-7, 6 sit in the trial range, and 1 reaches the 180 mcg trial dose. The combination shelf itself is not censusable from the NIH data, which is why each bottle’s K2 figure above is read from its listing or label and the source printed beside it.
| Item | Value (%) |
|---|---|
| MK-7 named | 72.5% |
| No form named | 22.3% |
| MK-4 named | 4.3% |
How we read the labels, and what did not hold
Method, vitamin D: 948 labels retrieved from the NIH Dietary Supplement Label Database on 2026-08-27; 573 sold as vitamin D with a vitamin D row were analysed and the 95 at exactly 5,000 IU read in full on 2026-09-18. Split-half by label-id parity: 17 of 21 checks held; not printed (4): 5,000 IU labels that are softgels; 5,000 IU labels that are capsules; 5,000 IU labels with an oil carrier; 5,000 IU labels directing "with a meal". Method, vitamin K2: 892 labels read (vitamin K2 per serving on the Supplement Facts panel, standalone K2 products only); 551 blends excluded; 6 of 6 findings held (in_range, at_or_above_floor, median_mcg, names_mk7, names_unnamed, names_mk4). The MK-4 sub-group (14 labels) is too small to validate and no figure from it is printed. Per-bottle K2 doses are read from the source named in the table, not from a census. Open data at /vitamin-d/5000-iu-with-k2.json (CC BY 4.0). What it cannot tell you: sales volume per label, whether a softgel contains what its label says (that is what USP and NSF marks are for), or anything about products that have not filed with the NIH.
Which vitamin D3 5000 IU with K2 to buy
Sports Research Vitamin D3 + K2 at $0.319 is the vegan option, lichen-sourced D3 with 100 mcg MK-7, on the best vitamin D ranking. The 5,000 IU page ranks every plain softgel; the vitamin K hub covers standalone K2.
Frequently asked questions
Do I need K2 with 5,000 IU of vitamin D3?
No trial shows you do. Vitamin D raises calcium absorption and K2 activates the proteins that keep calcium in bone and out of arteries; the combined D-plus-K trials show a small gain in bone density (pooled effect 0.316 across 8 trials), but none tested a 5,000 IU softgel and none shows K2 prevents a harm from 5,000 IU. Only 15.8% of the 95 5,000 IU labels filed with the NIH pair K2. Take the combination if you also want K2's own bone and arterial evidence; do not take it as a safety requirement. Our vitamin D with or without K2 guide goes through the trials.
How much MK-7 should a D3 + K2 softgel contain?
90 to 200 mcg, and the form should be MK-7, named on the label. The long trials used 180 mcg of MK-7 a day for 3 years; the median standalone K2 label sells 100 mcg and 63.6% of the 327 standalone K2 labels we read are inside the 90-200 mcg range. Of the 6 5,000 IU + K2 bottles we track, 6 are in that range; NOW Mega D-3 & MK-7 5,000 IU / 180 mcg is the only one at the 180 mcg trial dose. A bottle that says "with K2" but prints no microgram figure or no form has not told you what you are buying.
MK-7 or MK-4 in a vitamin D3 + K2 combo?
MK-7. It is absorbed as well as K1, peaks about 4 hours after a dose and has a much longer half-life, so it accumulates to 7- to 8-fold higher serum levels with daily use and carboxylates osteocalcin more completely; MK-4 has a half-life of hours and the trials that used it gave 45,000 mcg a day, a dose no combination softgel carries. 72.5% of standalone K2 labels name MK-7, 4.3% name MK-4 and 22.3% name no form at all. Every bottle on this page that states a form states MK-7.
Which vitamin D3 5000 IU with K2 is best?
On cost per dose with a stated MK-7 dose, Horbäach Vitamin D3 5000 IU + K2 MK-7 100 mcg at $0.055, 100 mcg of MK-7 per softgel. The USP Verified one is Nature Made Vitamin D3 5000 IU + K2 100 mcg at $0.419, the mark that tests potency against the label. NOW Mega D-3 & MK-7 5,000 IU / 180 mcg is the one at the 180 mcg MK-7 trial dose, $0.199 a day. Two separate bottles, the cheapest plain 5,000 IU plus the cheapest 100 mcg MK-7, cost $0.103 a day.
Is 5,000 IU of vitamin D3 too much, with or without K2?
It is above the Institute of Medicine's 4,000 IU upper limit and below the Endocrine Society's 10,000 IU, and raises 25(OH)D by roughly 35 ng/mL at equilibrium: a correction dose for a measured low level, obesity, malabsorption or little sun, not a maintenance dose. K2 does not change any of that. Test first, retest after 8 to 12 weeks, and read the 5,000 IU page for who the dose is for.
Can I take a D3 + K2 combo on warfarin?
Not without your prescriber. The K1-versus-MK-7 comparison found that preparations supplying 50 mcg a day or more of MK-7 can interfere with oral anticoagulant treatment in a clinically relevant way, and every bottle on this page supplies 100 mcg or more. Plain 5,000 IU vitamin D3 without K2 is the version for anyone on warfarin; the vitamin K and warfarin guide covers the rest.
Related guides
- Vitamin D: what to buy and how much
- Vitamin D with or without K2: the trials
- Vitamin D3 5000 IU: who needs it, cheapest verified
- Vitamin D dosage guide
- Best vitamin D supplement, ranked
- Vitamin K: K1 vs K2 and how much
- Vitamin K and warfarin
- Vitamin D side effects and toxicity
Sources
- Knapen MH, et al. “Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.” Osteoporos Int. 2013. PMID: 23525894
- Knapen MH, et al. “Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.” Thromb Haemost. 2015. PMID: 25694037
- Schurgers LJ, et al. “Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.” Blood. 2007. PMID: 17158229
- Kuang X, et al. “The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials.” Food Funct. 2020. PMID: 32219282
- van Ballegooijen AJ, et al. “The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review.” Int J Endocrinol. 2017. PMID: 29138634
- Heaney RP, et al. “Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol.” Am J Clin Nutr. 2003. PMID: 12499343
- Ross AC, et al. “The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know.” J Clin Endocrinol Metab. 2011. PMID: 21118827
- Manson JE, et al. “Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease.” N Engl J Med. 2019. PMID: 30415629
- NIH Office of Dietary Supplements. Dietary Supplement Label Database. dsld.od.nih.gov (vitamin D labels retrieved 2026-08-27, 5,000 IU labels read in full 2026-09-18; 892 vitamin K2 labels read).