What Is the Best Liquid B12 or B12 Drops?
The best liquid B12 is Pure Encapsulations B12 Liquid, ChatGPT’s first answer in 7 of 8 tries: 1,000 mcg of methylcobalamin in one dropper. Want more B12 for less? Why Not Natural gives 5,000 mcg for $10.99 a month. Nutricost costs $3.90. We checked 23.
By Erin Rose Updated November 2026 How we score
1. Our pick, the liquid ChatGPT names first
- B12
- 1,000 mcgFormulated with methylcobalamin
- Dose
- 1 mLOne full dropper
- Cost
- $22.00 a month$22.00 for 30 droppers
- Sweetened with
- Stevia onlyNo sugar on the label
Why we pick it ChatGPT names it first in 7 of the 8 answers we saved to this exact question. The label gives the dose for one full dropper, 1 mL, and lists five other ingredients with no sugar or flavoring: water, glycerin, citric acid, potassium sorbate and stevia.
Which one should you buy?
2. Why Not Natural 5,000 mcg: more B12 for less
Five times the B12 of our pick in 1 mL, for $11.01 less a month. The label lists three other ingredients: organic glycerin, water and organic cherry flavor, and says to hold it under your tongue for 30 seconds if you can. It is USDA Organic.
Why Not Natural Organic B12 Liquid
$10.99 a month · $21.97 for 60 servings
3. Nutricost 5,000 mcg: the lowest cost per mcg
The same 5,000 mcg of methylcobalamin in 1 mL, with only glycerin and water added. It costs the least for each mcg of B12 of the 21 in the table.
Nutricost Organic B12 Liquid Drops
$3.90 a month · $14.95 for about 115 servings
4. MaryRuth’s Methyl B12 Spray: for a spray
ChatGPT names it as its pick if you would rather spray than use a dropper. Two sprays give 1,500 mcg of methylcobalamin, made with organic glycerin, water, berry flavor and citric acid.
MaryRuth’s Organic Methyl B12 Spray
$5.74 a month · $22.95 for about 120 servings
Choose Pure Encapsulations for the 1,000 mcg dropper ChatGPT names first. Choose Why Not Natural for 5,000 mcg, organic, for less; Nutricost for the lowest cost per mcg; and MaryRuth’s if you would rather spray.
Six other 1,000 mcg liquids cost less a month. Douglas Laboratories ($20.00), ChatGPT’s second name in 5 of 8 answers, adds cherry flavor. ClarBio ($12.48) splits two forms. Bluebonnet’s two ($10.15 each) add fructose. Triquetra ($3.67) adds two more forms and folate, and NOW’s B-complex ($2.79) adds other B vitamins. Pure Encapsulations is plain methylcobalamin with no sugar or flavor.
Sixteen of 21 labels measure a serving by dropper or mL, and no label lists alcohol
We checked 23 liquid B12 supplements sold on Amazon: 19 drops, three sprays and one B-complex liquid. Not one of the 23 is on a third-party testing list. Thirteen use methylcobalamin alone, six mix it with other forms of B12, three use cyanocobalamin, and one uses adenosylcobalamin and hydroxocobalamin.
Of the 21 labels we read, 16 measure one serving with the dropper or in mL, 1 to 2 mL; two count drops, two are sprays, and NOW’s uses a quarter teaspoon. Five list a sugar (fructose in four, apple juice concentrate in one) and three a sugar alcohol (sorbitol or xylitol). No label lists alcohol.
Here are 21 in three groups. Our pick leads; each group then runs from lowest cost a month.
We also read nbpure Organic Methyl B12 Spray, 500 mcg a spray, and LiquidHealth Organic Methyl B12 drops with tart cherry, 5,000 mcg.
| Supplement | B12 a serving | Cost | Buy |
|---|---|---|---|
| Drops with 1,000 to 2,500 mcg | |||
 Pure Encapsulations B12 LiquidOur pick30 droppers | 1,000 mcg methylcobalamin in 1 mL (one dropper); stevia | $22.00 a month | See on Amazon |
 NOW Vitamin B-12 Complex Liquid59 servingsBest for the lowest cost a month | 1,000 mcg cyanocobalamin in 1/4 teaspoon, plus other B vitamins; xylitol | $2.79 a month | See on Amazon |
 Triquetra Health BioActive B12 Liquid180 servingsThree forms of B12 plus folate | 1,000 mcg in 4 drops: methylcobalamin 800, adenosylcobalamin 100, hydroxocobalamin 100; plus folate | $3.67 a month | See on Amazon |
 Bluebonnet Liquid Methylcobalamin 1,000 mcg59 droppersChatGPT names it too | 1,000 mcg methylcobalamin in 1 mL; fructose, raspberry | $10.15 a month | See on Amazon |
 Bluebonnet Liquid B12 and Folic Acid59 droppersAdds folic acid | 1,000 mcg cyanocobalamin plus folate in 1 mL; fructose, raspberry | $10.15 a month | See on Amazon |
 ClarBio Nutrition B12 Liquid60 servingsTwo forms, 500 mcg each | 1,000 mcg in 1 mL: methylcobalamin 500, adenosylcobalamin 500 | $12.48 a month | See on Amazon |
 Douglas Laboratories Liquid B1230 droppersChatGPT’s second name | 1,000 mcg methylcobalamin in 1 mL (one dropper); cherry | $20.00 a month | See on Amazon |
 Pure Encapsulations Adenosyl/Hydroxy B12 Liquid30 droppersFor a B12 without methylcobalamin | 1,000 mcg adenosylcobalamin and hydroxocobalamin in 1 mL | $35.00 a month | See on Amazon |
 Brain Body Nourish B12 2,500 mcg Liquid30 droppersTwo forms, organic glycerin and water | 2,500 mcg methylcobalamin and adenosylcobalamin in 1 mL | $35.00 a month | See on Amazon |
| Sprays | |||
 Garden of Life mykind Organics B-12 Spray140 spraysOrganic and vegan spray | 500 mcg methylcobalamin a spray; stevia, raspberry | $3.00 a month | See on Amazon |
| MaryRuth’s Organic Methyl B12 Sprayabout 120 servingsChatGPT’s spray pick | 1,500 mcg methylcobalamin in 2 sprays; berry | $5.74 a month | See on Amazon |
| Drops with 5,000 mcg or more | |||
| Nutricost Organic B12 Liquid Dropsabout 115 servingsBest for the lowest cost per mcg | 5,000 mcg methylcobalamin in 1 mL; glycerin and water only | $3.90 a month | See on Amazon |
 Nature’s Bounty B12 5,000 mcg Sublingual Liquid59 servingsHeld under the tongue for 30 seconds | 5,000 mcg cyanocobalamin in 1 mL; sorbitol, berry | $4.32 a month | See on Amazon |
 Nusava B12 5,000 mcg with B6 and B12 bottles, 80 servingsAdds other B vitamins | 5,000 mcg methylcobalamin in 1.5 mL, plus B1, B3, B6 and folic acid; monk fruit | $9.36 a month | See on Amazon |
 Carlyle B12 10,000 mcg Liquid Dropsabout 30 servingsThe most B12 a serving | 10,000 mcg cyanocobalamin and methylcobalamin in 2 mL; sorbitol | $9.49 a month | See on Amazon |
 VitBoost B12 Liquid Drops60 servingsRaspberry drops | 5,000 mcg methylcobalamin in 1 mL; fructose, raspberry | $9.95 a month | See on Amazon |
| Why Not Natural Organic B12 Liquid60 servingsUSDA Organic, cherry | 5,000 mcg methylcobalamin in 1 mL; organic cherry | $10.99 a month | See on Amazon |
 Pure TheraPro Rx BioActive B12 Liquid60 servingsThree forms in 4 drops | 5,000 mcg in 4 drops: methylcobalamin 2,500, adenosylcobalamin 1,500, hydroxocobalamin 1,000 | $10.99 a month | See on Amazon |
 Bluebonnet Liquid Methylcobalamin 5,000 mcg59 droppers | 5,000 mcg methylcobalamin in 1 mL; fructose, raspberry | $15.84 a month | See on Amazon |
 Global Healing B12 5,000 mcg Liquid Dropsabout 30 servingsThree forms, 5,000 mcg | 5,000 mcg in 1 mL: 60% methylcobalamin, 20% adenosylcobalamin, 20% hydroxocobalamin | $24.95 a month | See on Amazon |
 Pure Encapsulations B12 5,000 Liquid30 droppersOur pick’s 5,000 mcg sister | 5,000 mcg methylcobalamin in 1 mL (one dropper); apple juice concentrate and stevia | $39.00 a month | See on Amazon |
NIH: no form of B12 has been shown to work better
NIH says research has not shown that any form of supplemental B12 is better than the others, and it lists B12 that dissolves under your tongue among the forms sold. So any form is a fine pick, and a liquid suits you if you would rather not swallow a pill. For B12 you melt in your mouth instead, see the best sublingual B12; for two forms in one, methylcobalamin and adenosylcobalamin; and on forms, methylcobalamin vs cyanocobalamin.
The two labels, side by side
The two labels
Questions people ask
Who should take liquid B12?
NIH says people over 50 should get most of their B12 from fortified foods or supplements, and that people who eat little or no animal food might not get enough from their diets. A liquid suits anyone who would rather not swallow a pill.
How much liquid B12 should I take?
Adults need 2.4 mcg a day, says NIH. The labels here give 500 to 10,000 mcg a serving; NIH says doses such as 500 or 1,000 mcg are safe, though the body takes in only a small part, and that B12 has not been shown to cause any harm, even at high doses. More in is 1,000 mcg of B12 too much.
How we picked
On November 9, 2026 we read the labels of 23 liquid B12 drops and sprays on Amazon and searched five testing lists for each: NSF/ANSI 173, NSF Certified for Sport, Informed Choice, Informed Sport and USP Verified. We started from ChatGPT’s answers to this question and carried the products they name. Prices are Amazon’s, read November 9, 2026.
Sources
- Amazon listings and label photos of the 21 supplements above, prices read November 9, 2026; label panels from the NIH Dietary Supplement Label Database.
- Testing lists, read November 9, 2026: NSF/ANSI 173 list; NSF Certified for Sport; Informed Choice; Informed Sport; USP Verified.
- NIH Office of Dietary Supplements, Vitamin B12 fact sheet for consumers, read November 9, 2026.