What Is the Best B12 With Both Methylcobalamin and Adenosylcobalamin?
The best B12 with both methylcobalamin and adenosylcobalamin is Life Extension B12 Elite: ChatGPT names it first in 4 of 6 answers, and one lozenge gives 1,000 mcg of the two for $4.13 a month. Igennus Super B12-Complex costs $3.33 a month and prints 333 mcg of each of three forms. We checked 11.
By Erin Rose Updated November 2026 How we score
1. Our pick, the two-form lozenge ChatGPT names first
- B12
- 1,000 mcgMethyl + adenosyl
- Dose
- One a dayA lozenge that melts in your mouth
- Bottle
- $8.2560 lozenges on Amazon
- Label
- Both forms namedShown below
Why we pick it ChatGPT names it first in 4 of the 6 answers we saved to this question. It gives just the two forms you asked for: the label lists 1,000 mcg as adenosylcobalamin and methylcobalamin, and the Amazon listing says that is 500 mcg of each. Its listing gives 500 mcg of each of those two forms; Igennus gives 333 mcg of each and adds 333 mcg of hydroxocobalamin, and costs $0.80 less a month. The $8.25 bottle is the lowest price of the 11.
Which one should you buy?
2. Igennus Super B12-Complex: best for the lowest cost, every amount printed
1,000 mcg in a strawberry tablet that dissolves under your tongue. The label prints 333 mcg each of methylcobalamin, adenosylcobalamin and a third form, hydroxocobalamin. It costs the least a month of the 11 we checked.
Igennus Super B12-Complex
$3.33 a month · $19.95 for 180 tablets
3. KAL B-12 ActivMelt: 2,000 mcg, 1,000 of each form per its listing
2,000 mcg in a mixed berry micro tablet that melts in your mouth. Its listing says 1,000 mcg comes from each form; the label gives the total. ChatGPT named it first in one of its six answers.
KAL B-12 ActivMelt
$7.80 a month · $15.59 for 60 tablets
4. ClarBio Vitamin B12 Drops: best liquid with just the two forms
1,000 mcg in raspberry drops you hold under your tongue or add to a drink. The label prints 500 mcg of adenosylcobalamin and 500 mcg of methylcobalamin, the one label here with only these two forms that prints both amounts.
ClarBio Vitamin B12 Drops
$12.48 a month · $24.95 for 60 servings
Choose Life Extension for 500 mcg of each of the two forms, the one ChatGPT names first, Igennus for the lowest cost a month with every amount printed, KAL for 1,000 mcg of each form, and ClarBio for a liquid. The Triquetra Health liquid costs $3.67 a month and gives 100 mcg of adenosylcobalamin.
Six of 11 print each form’s amount on the label, and six add hydroxocobalamin
We checked 11 B12 supplements sold on Amazon with both methylcobalamin and adenosylcobalamin. Six print the amount of each form on the label: Igennus, both Triquetra Health products, Why Not Natural, Pure TheraPro Rx and ClarBio. The other five print the total only (Life Extension, KAL, Seeking Health, Source Naturals and Brain Body Nourish); the Life Extension and KAL listings give the split.
Six add hydroxocobalamin, a third form: Igennus, both Triquetra Health products, Why Not Natural, Pure TheraPro Rx and Source Naturals. Five give 1,000 mcg a serving; the other six give 2,000 to 5,000 mcg. Not one of the 11 is on a third-party testing list.
Here are all 11 in three groups. Our pick leads; each group then runs from lowest cost a month.
| Supplement | B12 a serving | Cost | Buy |
|---|---|---|---|
| Lozenges and tablets that melt in your mouth | |||
 Life Extension B12 EliteOur pick60 lozenges | 1,000 mcg; label names both forms, listing says 500 mcg each | $4.13 a month | See on Amazon |
| Igennus Super B12-Complex180 tabletsBest for the lowest cost a month | 1,000 mcg; label: 333 mcg each of methyl, adenosyl and hydroxo | $3.33 a month | See on Amazon |
| KAL B-12 ActivMelt60 micro tabletsTwo forms, 1,000 mcg of each per its listing | 2,000 mcg; label names both forms, listing says 1,000 mcg each | $7.80 a month | See on Amazon |
 Source Naturals Advanced B-12 Complex60 lozengesBest for three forms plus folic acid in a lozenge | 5,000 mcg; three forms, total only; with folic acid | $8.59 a month | See on Amazon |
 Seeking Health Methyl B12 100060 lozengesChatGPT names it in 5 of 6 answers; sweetened only with xylitol | 1,000 mcg; label names both forms, total only | $10.00 a month | See on Amazon |
| Capsules you swallow | |||
 Why Not Natural Vitamin B12 Complex60 capsulesBest for three forms plus methylfolate and spirulina | 5,000 mcg; label: 3,000 methyl, 1,000 adenosyl, 1,000 hydroxo; with methylfolate | $10.99 a month | See on Amazon |
 Triquetra Health BioActive B12 Capsules60 capsulesBest for the most methylcobalamin, 4,000 mcg | 5,000 mcg; label: 4,000 methyl, 500 adenosyl, 500 hydroxo; with methylfolate | $12.48 a month | See on Amazon |
| Liquid drops | |||
 Triquetra Health BioActive B12 Liquid180 servingsBest for the lowest cost liquid | 1,000 mcg; label: 800 methyl, 100 adenosyl, 100 hydroxo; with methylfolate | $3.67 a month | See on Amazon |
 Pure TheraPro Rx BioActive B12 Liquid10 mL, 60 servingsBest for the most adenosylcobalamin on a label, 1,500 mcg | 5,000 mcg; label: 2,500 methyl, 1,500 adenosyl, 1,000 hydroxo | $10.99 a month | See on Amazon |
| ClarBio Vitamin B12 Drops60 servingsBest for just the two forms, both amounts on the label | 1,000 mcg; label: 500 mcg methyl, 500 mcg adenosyl | $12.48 a month | See on Amazon |
 Brain Body Nourish B12 Liquid30 servingsBest for a three-ingredient organic liquid | 2,500 mcg; label names both forms, total only | $35.00 a month | See on Amazon |
Methylcobalamin and adenosylcobalamin are the two forms your body puts to work
NIH calls methylcobalamin and adenosylcobalamin the active forms of B12. Hydroxocobalamin and cyanocobalamin become active once the body turns them into one of those two. NIH also says no form of B12 in supplements has been shown to work better than another, so compare the label, the dose and the cost. For methylcobalamin alone, see the best methylcobalamin B12.
Adults need 2.4 mcg a day; these give 1,000 to 5,000 mcg
NIH sets the adult need at 2.4 mcg a day. It says doses such as 500 or 1,000 mcg are safe, though only a small part is absorbed. Read the Supplement Facts panel for the total in each serving, and the listing for how it splits between forms.
Life Extension’s label names both forms in one 1,000 mcg line; Igennus prints all three amounts
The two labels
Questions people ask
How much of each form is in Life Extension B12 Elite?
1,000 mcg in all. The label lists it in one line as adenosylcobalamin and methylcobalamin, and the Amazon listing says it is 500 mcg of each.
How do I take B12 Elite?
One lozenge a day. The label says to let it dissolve in your mouth, then swallow. A bottle of 60 lasts two months.
Is 5,000 mcg of B12 too much?
NIH says B12 has not been shown to cause harm, even at high doses, and that the body absorbs only a small part of a large dose. More in is 1,000 mcg of B12 too much.
What is hydroxocobalamin?
A third form of B12, found in Igennus and five other products here. NIH says the body turns it into methylcobalamin or adenosylcobalamin.
How we picked
We started from the 6 answers ChatGPT gave us to this exact question. On November 9, 2026 we read the labels and Amazon listings of 11 B12 supplements sold with both methylcobalamin and adenosylcobalamin and searched five testing lists for each: NSF/ANSI 173, NSF Certified for Sport, Informed Choice, Informed Sport and USP Verified. Prices are Amazon’s, read November 9, 2026.
Sources
- Amazon listings and label photos of the 11 supplements above, prices read November 9, 2026; label panels from the NIH Dietary Supplement Label Database.
- Testing lists, read November 9, 2026: NSF/ANSI 173 list; NSF Certified for Sport; Informed Choice; Informed Sport; USP Verified.
- NIH Office of Dietary Supplements, Vitamin B12 fact sheet for consumers and fact sheet for health professionals, read November 9, 2026.