Verified Supplement Data Evidence-based supplement comparisons

Supplement Research Tracker (2026): What's Being Studied Right Now

By Verified Supplement Data · Updated · Source: ClinicalTrials.gov · Methodology

Live data from ClinicalTrials.gov: We monitor the US government's clinical trials registry for active supplement research. Currently 756 studies are recruiting across 14 supplement categories. This page shows which supplements have the most active research — and what those studies are investigating.

Clinical trials are the gold standard of evidence. Before a supplement claim can be considered well-supported, it needs randomized controlled trials (RCTs) with adequate sample sizes. This tracker shows you where that evidence is actively being generated.

Research Momentum by Supplement

Sorted by number of actively recruiting studies. More recruiting trials = faster evidence accumulation.

Active clinical trial counts from ClinicalTrials.gov as of 2026-03-17.
Supplement Total Studies Recruiting Now Largest Trial Momentum
Creatine 1,783 230 4,310 participants Strong
Vitamin D 1,296 140 25,620 participants Strong
Iron 555 79 25,620 participants Strong
Probiotics 474 72 1,600 participants Strong
Omega-3 / Fish Oil 597 63 2,000 participants Strong
CoQ10 281 44 20,000 participants Strong
Zinc 338 36 25,620 participants Strong
Vitamin B12 254 33 25,620 participants Strong
Magnesium 254 26 3,253 participants Strong
Collagen 141 18 845 participants Growing
Ashwagandha 54 7 160 participants Emerging
L-Theanine 47 7 100 participants Emerging
Biotin 29 1 92 participants Limited
Tongkat Ali 3 0 Limited

What the Research Momentum Tells You

Strong momentum (20+ recruiting trials) means a supplement has significant institutional interest — universities and hospitals are investing resources to study it. This doesn't guarantee benefits, but it means the evidence base is actively growing.

Limited momentum doesn't mean a supplement is ineffective. Some supplements (like biotin for hair) have limited research because existing evidence already addresses the main questions, or because the market doesn't justify expensive trials.

Conversely, heavy research activity can signal unresolved questions. Vitamin D's 140+ recruiting trials reflect genuine scientific uncertainty about optimal dosing, which conditions it helps, and who benefits most.

Creatine: 230 Recruiting Trials Strong

Creatine research has expanded far beyond bodybuilding. Active trials are studying cognitive benefits, traumatic brain injury recovery, and depression — areas where early evidence is promising but definitive answers are still coming.

1,783 total studies · 230 currently recruiting · 55 completed in the last 2 years

Notable Recruiting Studies

Effect of High-intensity Statin With Ezetimibe COmbination theRapy Versus High-intensity sTatin Monotherapy After Percutaneous Coronary Intervention With Drug-eluting Stents; the ESCORT Trial

4,310 participants · Yonsei University · NA · Coronary Artery Disease Requiring Coronary Revascularization With Newer Generation DES Implantation

NCT05782777 on ClinicalTrials.gov

Myocardial Infarction Registry

2,500 participants · University Hospital Heidelberg · N/A · Acute Coronary Syndrome

NCT06128317 on ClinicalTrials.gov

Diagnosis and Prognosis for Aortic Aneurysm aNd Dissection in Anzhen(DPANDA) Study

1,500 participants · Beijing Institute of Heart, Lung and Blood Vessel Diseases · N/A · Aortic Aneurysm, Aortic Dissection

NCT03233087 on ClinicalTrials.gov

Read our Creatine supplement guide →

Vitamin D: 140 Recruiting Trials Strong

Vitamin D remains one of the most actively researched supplements. Current trials focus on immune function, autoimmune diseases, pregnancy outcomes, and COVID-19 recovery. The dosing debate (1,000 vs 5,000 IU) is still being settled.

1,296 total studies · 140 currently recruiting · 28 completed in the last 2 years

Notable Recruiting Studies

Healthy Mums, Healthy Babies: Multiple Micronutrient Supplementation in Ethiopia

25,620 participants · London School of Hygiene and Tropical Medicine · N/A · Birth Weight

NCT05708183 on ClinicalTrials.gov

Effects of Vitamin D3 and Yeast Beta-Glucan Supplementation on Glycemic Control and Cardiovascular Disease Risk in Patients With Type 2 Diabetes

2,500 participants · Huazhong University of Science and Technology · NA · Diabetes Mellitus, Type 2

NCT06861062 on ClinicalTrials.gov

VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma

2,000 participants · Professor Klaus Bønnelykke · Phase 3 · Asthma, Respiratory Tract Infections, Gastrointestinal Infection, Croup, Eczema, Allergy, Wheezing, Fractures, Bone, Development, Child, Cognition Disorders in Children, Psychiatric Diagnosis

NCT06570889 on ClinicalTrials.gov

Read our Vitamin D supplement guide →

Iron: 79 Recruiting Trials Strong

Iron supplementation research focuses on form optimization (bisglycinate vs sulfate), pregnancy outcomes, and chronic disease anemia. Several large trials are comparing tolerability of newer chelated forms.

555 total studies · 79 currently recruiting · 11 completed in the last 2 years

Notable Recruiting Studies

Healthy Mums, Healthy Babies: Multiple Micronutrient Supplementation in Ethiopia

25,620 participants · London School of Hygiene and Tropical Medicine · N/A · Birth Weight

NCT05708183 on ClinicalTrials.gov

Evaluation of REACTS-IN, an Intervention to Improve Nutrition, Hygiene, and Sexual and Reproductive Health Services

13,500 participants · McGill University · NA · Stunting, Gender Equality, Acceptability of Health Care, Diet; Deficiency, Empowerment

NCT06362837 on ClinicalTrials.gov

BEP Targeting Strategies in Ethiopia

6,750 participants · Harvard School of Public Health (HSPH) · NA · Small for Gestational Age at Delivery, Gestational Weight Gain, Stillbirth, Preterm Birth, Birth Weight, Maternal Anemia in Pregnancy, Before Birth, Neonatal Death, Perinatal Death

NCT06125860 on ClinicalTrials.gov

Read our Iron supplement guide →

Probiotics: 72 Recruiting Trials Strong

Probiotic research is moving toward precision — matching specific strains to specific conditions. Current trials study gut-brain axis effects, IBS, antibiotic-associated issues, and immune modulation.

474 total studies · 72 currently recruiting · 22 completed in the last 2 years

Notable Recruiting Studies

Probiotic Supplementation in Extremely Preterm Infants in Scandinavia

1,600 participants · Region Stockholm · NA · Necrotizing Enterocolitis, Death, Sepsis Newborn, Feeding Disorder Neonatal, Growth Acceleration

NCT05604846 on ClinicalTrials.gov

Prevalence of FGIDs and Probiotics Study

512 participants · Chulalongkorn University · NA · Functional Gastrointestinal Disorders, Infant Conditions

NCT06309199 on ClinicalTrials.gov

Dietary Modulation of Gut Microbiota in Overweight/Obese Adolescents and COVID-19 Infection

440 participants · Indonesia University · NA · Health Behavior, Child Development, Adolescent Obesity

NCT05623007 on ClinicalTrials.gov

Read our Probiotics supplement guide →

Omega-3 / Fish Oil: 63 Recruiting Trials Strong

Omega-3 trials continue to refine cardiovascular and neurological benefits. Large-scale studies are investigating triglyceride vs ethyl ester forms and optimal EPA-to-DHA ratios for different conditions.

597 total studies · 63 currently recruiting · 11 completed in the last 2 years

Notable Recruiting Studies

Fish Oil in pREgnancY for Personalized Prevention of Early Childhood Asthma

2,000 participants · Professor Klaus Bønnelykke · Phase 3 · Asthma, Respiratory Tract Infections, Gastrointestinal Infection, Croup, Eczema, Allergy, Wheezing, Fractures, Bone, Development, Child, Cognition Disorders in Children, Psychiatric Diagnosis

NCT06560255 on ClinicalTrials.gov

Immunonutritional Supplement After Total Gastrectomy in Patients With Stage III Gastric Cancer

696 participants · Jinling Hospital, China · NA · Stage III Gastric Cancer

NCT05253716 on ClinicalTrials.gov

Weight Cycling on Hyperandrogenemia and Insulin Resistance in Polycystic Ovary Syndrome

425 participants · Peking Union Medical College Hospital · NA · Polycystic Ovary Syndrome

NCT06545721 on ClinicalTrials.gov

Read our Omega-3 / Fish Oil supplement guide →

CoQ10: 44 Recruiting Trials Strong

CoQ10 research is active in heart failure, statin myopathy, migraine prevention, and fertility. The ubiquinol vs ubiquinone bioavailability question drives several ongoing trials.

281 total studies · 44 currently recruiting · 11 completed in the last 2 years

Notable Recruiting Studies

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

20,000 participants · Sanford Health · N/A · Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome, Prenatal Benign Hypophosphatasia, Perinatal Lethal Hypophosphatasia, Odontohypophosphatasia, Adult Hypophosphatasia, Childhood-onset Hypophosphatasia, Infantile Hypophosphatasia, Hypophosphatasia, Kabuki Syndrome, Bohring-Opitz Syndrome, Narcolepsy Without Cataplexy, Narcolepsy-cataplexy, Hypersomnolence Disorder, Idiopathic Hypersomnia Without Long Sleep Time, Idiopathic Hypersomnia With Long Sleep Time, Idiopathic Hypersomnia, Kleine-Levin Syndrome, Kawasaki Disease, Leiomyosarcoma, Leiomyosarcoma of the Corpus Uteri, Leiomyosarcoma of the Cervix Uteri, Leiomyosarcoma of Small Intestine, Acquired Myasthenia Gravis, Addison Disease, Hyperacusis (Hyperacousis), Juvenile Myasthenia Gravis, Transient Neonatal Myasthenia Gravis, Williams Syndrome, Lyme Disease, Myasthenia Gravis, Marinesco Sjogren Syndrome(Marinesco-Sjogren Syndrome), Isolated Klippel-Feil Syndrome, Frasier Syndrome, Denys-Drash Syndrome, Beckwith-Wiedemann Syndrome, Emanuel Syndrome, Isolated Aniridia, Axenfeld-Rieger Syndrome, Aniridia-intellectual Disability Syndrome, Aniridia - Renal Agenesis - Psychomotor Retardation, Aniridia - Ptosis - Intellectual Disability - Familial Obesity, Aniridia - Cerebellar Ataxia - Intellectual Disability, Aniridia - Absent Patella, Aniridia, Peters Anomaly - Cataract, Peters Anomaly, Potocki-Shaffer Syndrome, Silver-Russell Syndrome Due to Maternal Uniparental Disomy of Chromosome 11, Silver-Russell Syndrome Due to Imprinting Defect of 11p15, Silver-Russell Syndrome Due to 11p15 Microduplication, Syndromic Aniridia, WAGR Syndrome, Wolf-Hirschhorn Syndrome, 4p16.3 Microduplication Syndrome, 4p Deletion Syndrome, Non-Wolf-Hirschhorn Syndrome, Autosomal Recessive Stickler Syndrome, Stickler Syndrome Type 2, Stickler Syndrome Type 1, Stickler Syndrome, Mucolipidosis Type 4, X-linked Spinocerebellar Ataxia Type 4, X-linked Spinocerebellar Ataxia Type 3, X-linked Intellectual Disability - Ataxia - Apraxia, X-linked Progressive Cerebellar Ataxia, X-linked Non Progressive Cerebellar Ataxia, X-linked Cerebellar Ataxia, Vitamin B12 Deficiency Ataxia, Toxic Exposure Ataxia, Unclassified Autosomal Dominant Spinocerebellar Ataxia, Thyroid Antibody Ataxia, Sporadic Adult-onset Ataxia of Unknown Etiology, Spinocerebellar Ataxia With Oculomotor Anomaly, Spinocerebellar Ataxia With Epilepsy, Spinocerebellar Ataxia With Axonal Neuropathy Type 2, Spinocerebellar Ataxia Type 8, Spinocerebellar Ataxia Type 7, Spinocerebellar Ataxia Type 6, Spinocerebellar Ataxia Type 5, Spinocerebellar Ataxia Type 4, Spinocerebellar Ataxia Type 37, Spinocerebellar Ataxia Type 36, Spinocerebellar Ataxia Type 35, Spinocerebellar Ataxia Type 34, Spinocerebellar Ataxia Type 32, Spinocerebellar Ataxia Type 31, Spinocerebellar Ataxia Type 30, Spinocerebellar Ataxia Type 3, Spinocerebellar Ataxia Type 29, Spinocerebellar Ataxia Type 28, Spinocerebellar Ataxia Type 27, Spinocerebellar Ataxia Type 26, Spinocerebellar Ataxia Type 25, Spinocerebellar Ataxia Type 23, Spinocerebellar Ataxia Type 22, Spinocerebellar Ataxia Type 21, Spinocerebellar Ataxia Type 20, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 19/22, Spinocerebellar Ataxia Type 18, Spinocerebellar Ataxia Type 17, Spinocerebellar Ataxia Type 16, Spinocerebellar Ataxia Type 15/16, Spinocerebellar Ataxia Type 14, Spinocerebellar Ataxia Type 13, Spinocerebellar Ataxia Type 12, Spinocerebellar Ataxia Type 11, Spinocerebellar Ataxia Type 10, Spinocerebellar Ataxia Type 1 With Axonal Neuropathy, Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia - Unknown, Spinocerebellar Ataxia - Dysmorphism, Non Progressive Epilepsy and/or Ataxia With Myoclonus as a Major Feature, Spasticity-ataxia-gait Anomalies Syndrome, Spastic Ataxia With Congenital Miosis, Spastic Ataxia - Corneal Dystrophy, Spastic Ataxia, Rare Hereditary Ataxia, Rare Ataxia, Recessive Mitochondrial Ataxia Syndrome, Progressive Epilepsy and/or Ataxia With Myoclonus as a Major Feature, Posterior Column Ataxia - Retinitis Pigmentosa, Post-Stroke Ataxia, Post-Head Injury Ataxia, Post Vaccination Ataxia, Polyneuropathy - Hearing Loss - Ataxia - Retinitis Pigmentosa - Cataract, Muscular Atrophy - Ataxia - Retinitis Pigmentosa - Diabetes Mellitus, Non-hereditary Degenerative Ataxia, Paroxysmal Dystonic Choreathetosis With Episodic Ataxia and Spasticity, Olivopontocerebellar Atrophy - Deafness, NARP Syndrome, Myoclonus - Cerebellar Ataxia - Deafness, Multiple System Atrophy, Parkinsonian Type, Multiple System Atrophy, Cerebellar Type, Multiple System Atrophy, Maternally-inherited Leigh Syndrome, Machado-Joseph Disease Type 3, Machado-Joseph Disease Type 2, Machado-Joseph Disease Type 1, Leigh Syndrome, Late-onset Ataxia With Dementia, Infection or Post Infection Ataxia, GAD Ataxia, Hereditary Episodic Ataxia, Gliadin/Gluten Ataxia, Friedreich Ataxia, Fragile X-associated Tremor/Ataxia Syndrome, Familial Paroxysmal Ataxia, Exposure to Medications Ataxia, Episodic Ataxia With Slurred Speech, Episodic Ataxia Unknown Type, Episodic Ataxia Type 7, Episodic Ataxia Type 6, Episodic Ataxia Type 5, Episodic Ataxia Type 4, Episodic Ataxia Type 3, Episodic Ataxia Type 1, Epilepsy and/or Ataxia With Myoclonus as Major Feature, Early-onset Spastic Ataxia-neuropathy Syndrome, Early-onset Progressive Neurodegeneration - Blindness - Ataxia - Spasticity, Early-onset Cerebellar Ataxia With Retained Tendon Reflexes, Early-onset Ataxia With Dementia, Childhood-onset Autosomal Recessive Slowly Progressive Spinocerebellar Ataxia, Dilated Cardiomyopathy With Ataxia, Cataract - Ataxia - Deafness, Cerebellar Ataxia, Cayman Type, Cerebellar Ataxia With Peripheral Neuropathy, Cerebellar Ataxia - Hypogonadism, Cerebellar Ataxia - Ectodermal Dysplasia, Cerebellar Ataxia - Areflexia - Pes Cavus - Optic Atrophy - Sensorineural Hearing Loss, Brain Tumor Ataxia, Brachydactyly - Nystagmus - Cerebellar Ataxia, Benign Paroxysmal Tonic Upgaze of Childhood With Ataxia, Autosomal Recessive Syndromic Cerebellar Ataxia, Autosomal Recessive Spastic Ataxia With Leukoencephalopathy, Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay, Autosomal Recessive Spastic Ataxia - Optic Atrophy - Dysarthria, Autosomal Recessive Spastic Ataxia, Autosomal Recessive Metabolic Cerebellar Ataxia, Autosomal Dominant Spinocerebellar Ataxia Due to Repeat Expansions That do Not Encode Polyglutamine, Autosomal Recessive Ataxia, Beauce Type, Autosomal Recessive Ataxia Due to Ubiquinone Deficiency, Autosomal Recessive Ataxia Due to PEX10 Deficiency, Autosomal Recessive Degenerative and Progressive Cerebellar Ataxia, Autosomal Recessive Congenital Cerebellar Ataxia Due to MGLUR1 Deficiency, Autosomal Recessive Congenital Cerebellar Ataxia Due to GRID2 Deficiency, Autosomal Recessive Congenital Cerebellar Ataxia, Autosomal Recessive Cerebellar Ataxia-pyramidal Signs-nystagmus-oculomotor Apraxia Syndrome, Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome Due to WWOX Deficiency, Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome Due to TUD Deficiency, Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome Due to KIAA0226 Deficiency, Autosomal Recessive Cerebellar Ataxia-epilepsy-intellectual Disability Syndrome, Autosomal Recessive Cerebellar Ataxia With Late-onset Spasticity, Autosomal Recessive Cerebellar Ataxia Due to STUB1 Deficiency, Autosomal Recessive Cerebellar Ataxia Due to a DNA Repair Defect, Autosomal Recessive Cerebellar Ataxia - Saccadic Intrusion, Autosomal Recessive Cerebellar Ataxia - Psychomotor Retardation, Autosomal Recessive Cerebellar Ataxia - Blindness - Deafness, Autosomal Recessive Cerebellar Ataxia, Autosomal Dominant Spinocerebellar Ataxia Due to a Polyglutamine Anomaly, Autosomal Dominant Spinocerebellar Ataxia Due to a Point Mutation, Autosomal Dominant Spinocerebellar Ataxia Due to a Channelopathy, Autosomal Dominant Spastic Ataxia Type 1, Autosomal Dominant Spastic Ataxia, Autosomal Dominant Optic Atrophy, Ataxia-telangiectasia Variant, Ataxia-telangiectasia, Autosomal Dominant Cerebellar Ataxia, Deafness and Narcolepsy, Autosomal Dominant Cerebellar Ataxia Type 4, Autosomal Dominant Cerebellar Ataxia Type 3, Autosomal Dominant Cerebellar Ataxia Type 2, Autosomal Dominant Cerebellar Ataxia Type 1, Autosomal Dominant Cerebellar Ataxia, Ataxia-telangiectasia-like Disorder, Ataxia With Vitamin E Deficiency, Ataxia With Dementia, Ataxia - Oculomotor Apraxia Type 1, Ataxia - Other, Ataxia - Genetic Diagnosis - Unknown, Acquired Ataxia, Adult-onset Autosomal Recessive Cerebellar Ataxia, Alcohol Related Ataxia, Multiple Endocrine Neoplasia, Multiple Endocrine Neoplasia Type II, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2, Multiple Endocrine Neoplasia, Type IV, Multiple Endocrine Neoplasia, Type 3, Multiple Endocrine Neoplasia (MEN) Syndrome, Multiple Endocrine Neoplasia Type 2B, Multiple Endocrine Neoplasia Type 2A, Atypical Hemolytic Uremic Syndrome, Atypical HUS, Wiedemann-Steiner Syndrome, Breast Implant-Associated Anaplastic Large Cell Lymphoma, Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA), Hemophagocytic Lymphohistiocytosis, Behcet's Disease, Alagille Syndrome, Inclusion Body Myopathy With Early-onset Paget Disease and Frontotemporal Dementia (IBMPFD), Lowe Syndrome, Pitt Hopkins Syndrome, 1p36 Deletion Syndrome, Jansen Type Metaphyseal Chondrodysplasia, Cockayne Syndrome, Chronic Recurrent Multifocal Osteomyelitis, CRMO, Malan Syndrome, Hereditary Sensory and Autonomic Neuropathy Type Ie, VCP Disease, Hypnic Jerking, Sleep Myoclonus, Mollaret Meningitis, Recurrent Viral Meningitis, CRB1, Leber Congenital Amaurosis, Retinitis Pigmentosa, Rare Retinal Disorder, KCNMA1-Channelopathy, Primary Biliary Cirrhosis, ZMYND11, Transient Global Amnesia, Glycogen Storage Disease, Alstrom Syndrome, White Sutton Syndrome, DNM1, EIEE31, Myhre Syndrome, Recurrent Respiratory Papillomatosis, Laryngeal Papillomatosis, Tracheal Papillomatosis, Refsum Disease, Nicolaides Baraitser Syndrome, Leukodystrophy, Tango2, Cauda Equina Syndrome, Rare Gastrointestinal Disorders, Achalasia-Addisonian Syndrome, Achalasia Cardia, Achalasia Icrocephaly Syndrome, Anal Fistula, Congenital Sucrase-Isomaltase Deficiency, Eosinophilic Gastroenteritis, Idiopathic Gastroparesis, Hirschsprung Disease, Rare Inflammatory Bowel Disease, Intestinal Pseudo-Obstruction, Scleroderma, Short Bowel Syndrome, Sacral Agenesis, Sacral Agenesis Syndrome, Caudal Regression, Scheuermann Disease, SMC1A Truncated Mutations (Causing Loss of Gene Function), Cystinosis, Juvenile Nephropathic Cystinosis, Nephropathic Cystinosis, Kennedy Disease, Spinal Bulbar Muscular Atrophy, Warburg Micro Syndrome, Mucolipidoses, Mitochondrial Diseases, Mitochondrial Aminoacyl-tRNA Synthetases, Mt-aaRS Disorders, Hypertrophic Olivary Degeneration, Non-Ketotic Hyperglycinemia, Fish Odor Syndrome, Halitosis, Isolated Congenital Asplenia, Lambert Eaton (LEMS), Biliary Atresia, STAG1 Gene Mutation, Coffin Lowry Syndrome, Borjeson-Forssman-Lehman Syndrome, Blau Syndrome, Arginase 1 Deficiency, HSPB8 Myopathy, Beta-Mannosidosis, TBX4 Syndrome, DHDDS Gene Mutations, MAND-MBD5-Associated Neurodevelopmental Disorder, Constitutional Mismatch Repair Deficiency (CMMRD), SPATA5 Disorder, SPATA5L1 Related Disorder, Acrodysostosis, Multi-systematic Smooth Muscle Dysfunction Syndrome, CRELD1 (Cysteine Rich With EGF Like Domains 1), GNB1 Syndrome, Pyruvate Dehydrogenase Complex Deficiency Disease, Beta Mannosidosis, Kbg Syndrome, Labrune Syndrome, Metachromatic Leukodystrophy (MLD), Moyamoya Disease, OPHN1 Syndrome, Oculopharyngeal Muscular Dystrophy (OPMD), TUBB3 Mutation, WOREE (WWOX-related Epileptic Encephalopathy, SCAR12, Skraban-Deardorff Syndrome, Hereditary Myopathy With Early Respiratory Failure

NCT01793168 on ClinicalTrials.gov

Global Registry and Natural History Study for Mitochondrial Disorders

6,000 participants · LMU Klinikum · N/A · Mitochondrial Diseases, Kearns-Sayre Syndrome, MIDD, SANDO, SCAE, NARP Syndrome, MELAS Syndrome, MERRF Syndrome, Coenzyme Q10 Deficiency, LHON, MNGIE, MIRAS, Barth Syndrome, MDS, Mitochondrial Myopathies, Leigh Syndrome, Pearson Syndrome, CPEO

NCT05554835 on ClinicalTrials.gov

A Danish Pragmatic Randomized Trial of Nutritional Supplements in Heart Failure

4,044 participants · Tor Biering-Sørensen · Phase 3 · Heart Failure

NCT06694727 on ClinicalTrials.gov

Read our CoQ10 supplement guide →

How to Read This Data

This tracker pulls from ClinicalTrials.gov, the US government's registry of clinical studies. Every clinical trial conducted in the US (and many international trials) must be registered here.

  • Recruiting: The study is actively enrolling participants. Results are pending.
  • Active, not recruiting: Enrolled participants are being studied but no new participants are accepted.
  • Completed: The study has finished. Results may or may not be published yet.
  • Enrollment size matters: A 5,000-person trial carries far more statistical power than a 30-person pilot study.
  • Phase matters: Phase 3 and Phase 4 trials provide the strongest evidence. Phase 1-2 trials are preliminary.

Frequently Asked Questions

How do I find supplement clinical trials near me?

Visit ClinicalTrials.gov and search for the supplement you're interested in. Use the "Recruiting" status filter and enter your location. Many supplement trials accept healthy volunteers and may offer free supplements and health monitoring during the study.

Can I join a supplement clinical trial?

Yes. Many supplement trials recruit healthy adults. Eligibility criteria vary — some require specific conditions (e.g., vitamin D deficiency), while others study effects in healthy people. Check the inclusion/exclusion criteria on each trial's ClinicalTrials.gov page.

What does "research momentum" mean?

Research momentum reflects how many clinical trials are actively recruiting participants for a supplement. "Strong" means 20+ recruiting trials, "Growing" means 10-19, "Emerging" means 5-9, and "Limited" means fewer than 5. More recruiting trials suggest higher research interest and faster evidence accumulation.

How often is this data updated?

We query the ClinicalTrials.gov API regularly to keep this tracker current. The data source is the official US government clinical trials registry, which is updated by trial investigators in real time.

Why does creatine have so many trials?

Creatine is the most-researched supplement in history with over 500 published studies. Current research has expanded beyond athletics into cognitive performance, traumatic brain injury, depression, and aging — driving a large number of new trials.

Other Research Resources

Data Source

All data on this page is sourced from the ClinicalTrials.gov API v2, the official US government database of clinical studies. Data retrieved 2026-03-17. Trial counts reflect studies matching supplement-specific search terms with status filters for recruiting, active, and recently completed studies.