How much CoQ10 should I take?
Most CoQ10 products we score hold 200 mg (6 of 9) or 100 mg (3 of 9). The heart-failure and migraine trials that found a benefit used 300 mg a day, given as 100 mg three times a day. We found no official daily amount or upper limit. Doses of 1,200 and 2,400 mg a day were well tolerated in a Parkinson’s trial. Read the cautions before you start.
By Erin Rose Updated October 12, 2026 How we score
Which CoQ10 to buy for your dose
Match the bottle to the amount you want. The label states the CoQ10 per softgel or capsule. Our overall pick is Nature Made CoQ10 200 mg, third below.
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You want 200 mg a day at a low cost
Doctor's Best High Absorption CoQ10 with BioPerine 200 mg $0.33 a capsule
200 mg of ubiquinone (the standard form) in one capsule, with BioPerine (black pepper extract). Its label says USP Verified, but USP’s list (our copy) does not include it. Not on a public testing list.
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You want the lowest cost per 200 mg
Nutricost CoQ10 200 mg $0.30 a capsule
200 mg of CoQ10 a capsule, the lowest cost per 200 mg of the 9 we score. The label doesn’t name the form. Not on a public testing list.
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Our overall pick, on a testing list
Nature Made CoQ10 200 mg $0.62 a softgel
200 mg of CoQ10 in oil a softgel. On USP Verified.
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You want 100 mg, or 300 mg as three softgels
Qunol Ultra CoQ10 100 mg $0.25 a softgel (100 mg), about $0.50 per 200 mg
100 mg of solubilized CoQ10 (made to mix with water) a softgel, so you can take one, two or three. Not on a public testing list.
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You want ubiquinol
Qunol Ubiquinol Extra Strength 200 mg $0.67 a softgel
200 mg of ubiquinol (a form your body also makes from ubiquinone) a softgel. It costs more, and its absorption edge is uncertain. Not on a public testing list.
The doses the trials used
| What was studied | Dose | For |
|---|---|---|
| Heart failure (added to standard care) | 300 mg a day, as 100 mg three times | 2 years (Mortensen 2014) |
| Migraine prevention | 300 mg a day, as 100 mg three times | 3 months (Sándor 2005) |
| Studies in people at high heart risk | 100 to 200 mg a day | about 3 months (Flowers 2014) |
| Blood-level study | 200 mg a day | 4 weeks (Langsjoen 2014) |
| Parkinson’s (no benefit found) | 1,200 or 2,400 mg a day | up to 16 months (QE3 2014) |
The heart-failure trial found fewer serious heart events over 2 years; the migraine trial found fewer attacks. The studies in people at high heart risk did not report heart events (Flowers 2014), and the Parkinson’s trial found no benefit. See what CoQ10 helps with.
Why there is no official amount
We found no recommended daily amount (RDA) or official upper limit for CoQ10, and NIH has no dietary fact sheet for it. A safety review found side effects were no more common at 1,200 mg a day than at 60 mg, and called 1,200 mg an “observed safe level” (Hathcock 2006; its authors work for a supplement-industry group). In a large Parkinson’s trial, 1,200 and 2,400 mg a day were well tolerated (QE3 2014).
Form and absorption
CoQ10 dissolves in fat, and most labels say to take it with a meal. Your body absorbs less of a big dose (Bhagavan 2007; its authors work for Tishcon, a CoQ10 maker).
For which form or softgel absorbs best, read ubiquinol vs ubiquinone.
What the bottles hold
Of the 9 CoQ10 supplements we score, 6 have 200 mg a serving and 3 have 100 mg; 4 are ubiquinol. Cost per 200 mg runs from $0.30 to $1.70 at each brand’s list price. See what CoQ10 costs.
Cautions
- Warfarin and insulin. NIH says CoQ10 may interact with both. A small trial at 100 mg a day found no change in warfarin dose (Engelsen 2003), but ask your doctor before starting.
- Heart failure. The trial that found benefit tested CoQ10 added to standard care, so take it with your heart doctor’s OK.
- Mild side effects such as trouble sleeping or an upset stomach can happen; no serious side effects have been reported (NIH).
- Cancer treatment. NIH says CoQ10 may not be compatible with some cancer treatments. Ask your care team.
Questions
How much CoQ10 should I take a day?
We found no official amount. The heart-failure and migraine trials that found a benefit used 300 mg a day, as 100 mg three times a day (Mortensen 2014; Sándor 2005). Ask your doctor what fits you.
Is 400 mg of CoQ10 too much?
Probably not for safety: a safety review found no more side effects at 1,200 mg a day than at 60 mg (Hathcock 2006; its authors work for a supplement-industry group). But no trial we read shows more benefit above 300 mg.
Should I split my CoQ10 dose?
The heart-failure and migraine trials gave 100 mg three times a day (Mortensen 2014; Sándor 2005). Your body absorbs less of a big dose (Bhagavan 2007; its authors work for Tishcon, a CoQ10 maker). We did not look for a study that compares splitting a dose with taking it once.
Does CoQ10 interact with warfarin?
NIH says it may. See the warfarin note under Cautions on this page, and ask your doctor before starting.
Sources
- NIH National Center for Complementary and Integrative Health. Coenzyme Q10 (last updated January 2019; read October 12, 2026).
- Mortensen SA, et al. JACC Heart Fail. 2014. PubMed 25282031. Sándor PS, et al. Neurology. 2005. PubMed 15728298
- Flowers N, et al. Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2014. PubMed 25474484
- Hathcock JN, Shao A. Risk assessment for coenzyme Q10 (Ubiquinone). Regul Toxicol Pharmacol. 2006. PubMed 16814438
- Parkinson Study Group QE3 Investigators. JAMA Neurol. 2014. PubMed 24664227
- Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007. PubMed 17482886
- Langsjoen PH, Langsjoen AM. Clin Pharmacol Drug Dev. 2014. PubMed 27128225
- Engelsen J, et al. Ugeskr Laeger. 2003. PubMed 12772396