Verified Supplement Data Evidence-based supplement comparisons

What Supplements Does Your DNA Actually Need?

Upload your 23andMe or AncestryDNA file. Free results in 60 seconds.

100% Private — your DNA data never leaves your device. Nothing is uploaded.

Drop your DNA file here to see your results

Works with 23andMe and AncestryDNA (.txt files)

or click to browse

How it works
  • We scan 10 genetic markers (MTHFR, VDR, COMT, and more) that affect how your body absorbs supplements.
  • You get personalized recommendations: which supplement forms, doses, and blood tests are right for your genetics.
  • Everything runs in your browser. Your file never touches a server.
Disclaimer: This tool provides educational genetic information, not medical advice. Always discuss supplement changes with your doctor. Product links may earn a commission at no cost to you. Methodology · About

By Verified Supplement Data · Updated

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Frequently Asked Questions

What genetic data files are supported?

We support raw data files from 23andMe and AncestryDNA. These are plain text (.txt) files you can download from your account settings on either platform. The file contains your genotype data in a tab-delimited format. Other formats (VCF, Nebula, etc.) are not currently supported.

Is my genetic data private?

Yes, completely. Your genetic data file is read and analyzed entirely within your web browser using JavaScript. No genetic data is ever uploaded to our servers, transmitted over the internet, or stored anywhere. The file never leaves your device. You can verify this by disconnecting from the internet before running the analysis — it will still work.

What is MTHFR and why does it matter for supplements?

MTHFR (methylenetetrahydrofolate reductase) is an enzyme that converts folic acid to its active form, methylfolate (5-MTHF). The C677T variant (rs1801133) reduces enzyme activity by 35% with one copy and 70% with two copies. This affects 10-15% of the population. People with MTHFR variants should use methylfolate (5-MTHF) instead of folic acid. Learn more about active B vitamins.

Should I take methylfolate if I have MTHFR variants?

If you have one or two copies of the MTHFR C677T variant (CT or TT genotype), switching from folic acid to methylfolate (5-MTHF) at 400-800mcg daily is generally recommended. Methylfolate bypasses the impaired MTHFR enzyme entirely. Also ensure adequate vitamin B12 as methylcobalamin. Get homocysteine levels tested to monitor. See our methylfolate guide.

How accurate is this analysis?

The SNP matching is deterministic, not probabilistic — we read the exact genotype from your raw data file. 23andMe and AncestryDNA have >99.5% concordance with clinical-grade sequencing for common SNPs. The interpretations are based on published peer-reviewed research. However, genetics is only one factor — blood tests, diet, lifestyle, and medications all influence your supplement needs.

What should I do after getting my results?

Use your genetic results as a starting point, not a final answer. (1) Get blood work — homocysteine for MTHFR, 25(OH)D for vitamin D variants, B12 levels for FUT2. (2) Discuss with your doctor. (3) Start one change at a time so you can gauge the effect. (4) Retest after 3 months to confirm your protocol is working. Use our stack builder to combine genetic insights with your medications and goals.