{
  "dataset": "urolithin-a-cost-by-brand",
  "title": "Urolithin A Supplements Compared — the two products with a live Amazon price, neither a clean trial match",
  "sourcePage": "https://verifiedsupplementdata.com/urolithin-a/best-overall/",
  "license": "CC-BY-4.0",
  "licenseUrl": "https://creativecommons.org/licenses/by/4.0/",
  "attribution": "Verified Supplement Data (2026), Urolithin A Cost Comparison",
  "dateModified": "2026-07-18",
  "methodology": "The product used in every human trial cited here — Timeline Mitopure, 500mg free urolithin A — is sold mostly direct-to-consumer and has no reliable, stable Amazon buy-box price, so it is excluded from this dataset (editorial mention only, no buy button). Of the two products WITH a live Amazon price: Pure Encapsulations Renual (moleculeForm=free-urolithin-a) carries the correct Mitopure-branded free-urolithin-A molecule but at 250mg per serving — half the lowest dose (500mg) shown to improve strength (Singh 2022) — bundled with resveratrol and CoQ10, which dilutes cost-per-mg of the urolithin A itself. Nutri Urolithin A Diacetate (moleculeForm=diacetate) delivers 1000mg/day, matching the most-used trial dose (1000mg) numerically, but urolithin A diacetate is an ester/prodrug form that was NOT the molecule tested in any of the 7 human trials cited on this site — dose-equivalence to the free-urolithin-A trials should not be assumed. costPerMg is included for reference only and is NOT a fair apples-to-apples comparison across the two molecular forms. Dropped from this dataset after web research found no confirmed live price: Double Wood Urolithin A 500mg (also missing from the brand's own DTC catalog) and Toniiq Urolithin A Complex (the 500mg urolithin A is bundled into a 1,500mg 4-in-1 formula, precluding a clean single-ingredient comparison). EVIDENCE CONTEXT (human RCTs only; funding disclosed per trial — 5 of 7 are Amazentis-funded, the company behind Mitopure): Andreux 2019 (PMID 32694802, safety/PK, n=60, Amazentis-funded) established dose-dependent bioavailability up to 2,000mg single-dose and 1,000mg/day for 28 days, no serious adverse events. Singh 2022 (PMID 35584623, RCT n=88/79 completed, 4 months, fully Amazentis-funded) found hamstring strength +~12% at BOTH 500mg and 1,000mg, VO2/6MWT gains only at 1,000mg — the strongest positive trial in this pack. Liu 2022 (PMID 35050355, RCT n=66, older adults 65-90y, 4 months, partially Amazentis-funded) found PRIMARY endpoints (6MWT, ATP production) NULL, secondary muscle-endurance positive. Zhao 2024 (PMID 39487653, RCT n=20, young trained athletes, 8 weeks, INDEPENDENTLY funded — Jiangsu Province grant, no COI) found functional endurance improved, 1RM strength NOT significant — the one non-Amazentis trial. Whitfield 2025 (PMID 40839339, RCT n=42, elite distance runners, 4 weeks, Amazentis-funded) found PRIMARY 3000m time trial NULL, secondary VO2max/creatine-kinase positive. Monsalve Acevedo 2025 (PMID 41245402, pilot RCT n=20, adolescent soccer players, 6 weeks, partially industry-adjacent) found endurance improved with a wide confidence interval. No lifespan, anti-aging, or disease-outcome claim is made or supported at any dose. This statement has not been evaluated by the FDA; these products are not intended to diagnose, treat, cure, or prevent any disease.",
  "headline": {
    "productsCompared": 2,
    "trialLowMg": 500,
    "trialHighMg": 1000,
    "safetyCeilingMg": 2000,
    "freeUrolithinAPickBrand": "Pure Encapsulations",
    "freeUrolithinAPickMg": 250,
    "diacetatePickBrand": "Nutri",
    "diacetatePickMg": 1000,
    "trialGradeProductLiveOnAmazon": false,
    "note": "Ranked by molecular-form disclosure FIRST, cost per day second — never by cost per mg alone or by commissions. Neither product is a clean trial-dose match; the actual trial-grade product (Timeline Mitopure) is DTC-only."
  },
  "columns": [
    "brand",
    "product",
    "slug",
    "form",
    "moleculeForm",
    "mgPerServing",
    "servings",
    "price",
    "costPerServing",
    "costPerDay",
    "costPerMg",
    "verdict",
    "thirdParty"
  ],
  "units": {
    "mgPerServing": "mg (free urolithin A or diacetate — see moleculeForm)",
    "price": "USD",
    "costPerServing": "USD/serving",
    "costPerDay": "USD/day",
    "costPerMg": "USD per mg (not comparable across molecular forms)"
  },
  "citations": [
    {
      "claim": "First-in-human trial, n=60 sedentary elderly 61-85y: single ascending dose 250-2,000mg + 28-day multiple ascending dose 250/500/1,000mg/day. Safety favorable at every dose; dose-dependent bioavailability, unaffected by food, no accumulation.",
      "source": "Andreux PA, et al. 2019, Nature Metabolism",
      "pmid": "32694802"
    },
    {
      "claim": "n=100+ healthy adults: only ~40% reliable natural \"producers\" of urolithin A from dietary ellagitannins; direct supplementation gave >6-fold higher, more consistent plasma exposure than pomegranate juice. Mechanistic/rationale citation, not an efficacy trial.",
      "source": "Singh A, et al. 2021, European Journal of Clinical Nutrition",
      "pmid": "34117375"
    },
    {
      "claim": "RCT n=66, older adults 65-90y, 1,000mg/day x4 months. PRIMARY endpoints (6-minute walk distance; hand-muscle ATP production) NOT significant. SECONDARY: muscle endurance improved at 2 and 4 months; CRP decreased.",
      "source": "Liu S, et al. 2022, JAMA Network Open",
      "pmid": "35050355"
    },
    {
      "claim": "RCT n=88/79 completed, untrained overweight adults 40-65y, 4 months: 500mg and 1,000mg vs placebo. Hamstring strength +~12% at both doses (p=0.027-0.029); VO2/6MWT significant only at 1,000mg. Fully Amazentis-funded.",
      "source": "Singh A, et al. 2022, Cell Reports Medicine",
      "pmid": "35584623"
    },
    {
      "claim": "RCT n=20, young trained male athletes, 8 weeks, 1,000mg/day. Functional endurance (reps-to-failure) improved (p=0.011); 1RM strength NOT significant. Independently funded (Jiangsu Province grant), explicit no-COI.",
      "source": "Zhao J, et al. 2024, Journal of the International Society of Sports Nutrition",
      "pmid": "39487653"
    },
    {
      "claim": "RCT n=42, highly-trained male distance runners, 4-week altitude camp, 1,000mg/day. PRIMARY 3000m time trial NOT significant. SECONDARY: VO2max increase larger in UA group; creatine kinase significantly reduced.",
      "source": "Whitfield J, et al. 2025, Sports Medicine",
      "pmid": "40839339"
    },
    {
      "claim": "Pilot RCT n=20, adolescent academy soccer players, 6 weeks, 1,000mg/day. Yo-Yo IRT1 endurance improved ~239m more than placebo (95% CI 20-454, p=0.048, wide interval). Partially industry-adjacent funding (travel reimbursement only).",
      "source": "Monsalve Acevedo N, et al. 2025, Frontiers in Nutrition",
      "pmid": "41245402"
    }
  ],
  "products": [
    {
      "brand": "Nutri",
      "product": "Urolithin A DIACETATE",
      "slug": "nutri-urolithin-a-diacetate",
      "form": "Capsule (diacetate ester/prodrug)",
      "moleculeForm": "diacetate",
      "mgPerServing": 1000,
      "servings": 15,
      "price": 31.67,
      "costPerServing": 2.11,
      "costPerDay": 2.11,
      "costPerMg": 0.0021,
      "verdict": "different-molecule-not-trial-tested",
      "thirdParty": "No third-party testing disclosed"
    },
    {
      "brand": "Pure Encapsulations",
      "product": "Renual",
      "slug": "pure-encapsulations-renual",
      "form": "Capsule (caplique)",
      "moleculeForm": "free-urolithin-a",
      "mgPerServing": 250,
      "servings": 30,
      "price": 79,
      "costPerServing": 2.63,
      "costPerDay": 2.63,
      "costPerMg": 0.0105,
      "verdict": "under-trial-dose",
      "thirdParty": "Mitopure-branded free urolithin A (Amazentis raw material, the ingredient used in every human trial cited on this site) — bundled with resveratrol 150mg + CoQ10 60mg per serving"
    }
  ]
}