{
  "dataset": "tocotrienols-cost-by-brand",
  "title": "Tocotrienol Supplements Compared — cost per mg, annatto vs palm vs mixed-tocopherol sourcing",
  "sourcePage": "https://verifiedsupplementdata.com/tocotrienols/best-overall/",
  "license": "CC-BY-4.0",
  "licenseUrl": "https://creativecommons.org/licenses/by/4.0/",
  "attribution": "Verified Supplement Data (2026), Tocotrienols Cost Comparison",
  "dateModified": "2026-07-19",
  "methodology": "Six products tracked. Five disclose an actual tocotrienol mg per serving, so cost per mg is computable for those: costPerMg = price / (servings x disclosed tocotrienol mg per serving). One product (NOW Advanced Gamma E Complex) does not break out a tocotrienol-specific mg from its \"Mixed Tocopherols & Tocotrienols\" blend — its cost-per-mg is null/unknowable and it is EXCLUDED from the per-mg ranking, shown separately as a label-literacy caution example. \"sourceType\" is the PRIMARY ranking axis on the best-overall page, not price: annatto-tocopherol-free (Bixa orellana-derived, naturally free of tocopherol), palm-full-spectrum (contains all four tocotrienol isomers plus native tocopherol), or mixed-tocopherol-blend (a tocopherol-dominant product that also contains some tocotrienols, isomer mg not disclosed). This sourcing emphasis exists because one foundational cholesterol trial (Qureshi 1995, PMID 8614309) found co-administered alpha-tocopherol ATTENUATED the tocotrienol cholesterol-lowering effect, a mechanism supported by rat tissue-distribution data (PMID 22042641) — so tocopherol-free sourcing is a real, evidence-grounded distinction, not just marketing. EVIDENCE CONTEXT (do not treat any of this as a proven cholesterol or fatty-liver treatment): the largest quantitative synthesis in this evidence base, a 2020 meta-analysis of 15 RCTs (PMID 32951713), found tocotrienol supplementation does NOT significantly decrease LDL-C, TC, or TG; an independent CSIRO RCT (PMID 27760402) found no effect on vascular function or any CVD risk factor. The more promising signal is NAFLD/fatty liver (Pervez et al. RCTs, PMID 32951743 and 35933083), but that evidence comes from largely one research group, and the best head-to-head trial found delta-tocotrienol only EQUIVALENT to (not better than) standard alpha-tocopherol on the primary liver endpoints. This statement has not been evaluated by the FDA; these products are not intended to diagnose, treat, cure, or prevent any disease.",
  "headline": {
    "productsCompared": 6,
    "annattoTocopherolFree": 4,
    "palmFullSpectrum": 1,
    "mixedTocopherolBlend": 1,
    "typicalLowMg": 100,
    "typicalHighMg": 300,
    "nafldTrialDoseMg": 600,
    "boneTrialDoseLowMg": 430,
    "boneTrialDoseHighMg": 860,
    "cheapestPerMg": 0.0037,
    "cheapestPerMgBrand": "Wellness Extract",
    "cheapestPerDayBrand": "NOW Foods",
    "cheapestAnnattoBrand": "Wellness Extract",
    "note": "The cheapest cost per day overall (NOW Advanced Gamma E Complex) does not disclose a tocotrienol-specific mg — it is a mixed tocopherol/tocotrienol blend, excluded from the cost-per-mg ranking and flagged as a label-literacy caution example, not a top pick. Among products that disclose a dose, Healthy Origins Tocomin SupraBio (palm/full-spectrum) is cheapest per day but is also the lowest absolute dose (50mg) and contains native tocopherol. Ranked by sourceType (annatto-tocopherol-free vs palm-full-spectrum vs mixed-tocopherol-blend) FIRST on the best-overall page, cost second — never treat any of these as a proven cholesterol or fatty-liver treatment."
  },
  "columns": [
    "brand",
    "product",
    "slug",
    "form",
    "mgPerServing",
    "tocotrienolMgPerServing",
    "servings",
    "price",
    "costPerServing",
    "costPerDay",
    "costPerMg",
    "sourceType",
    "thirdParty"
  ],
  "units": {
    "mgPerServing": "mg tocotrienols (label)",
    "price": "USD",
    "costPerServing": "USD/serving",
    "costPerDay": "USD/day",
    "costPerMg": "USD per mg of tocotrienols"
  },
  "citations": [
    {
      "claim": "Meta-analysis of 15 RCTs / 20 arms: tocotrienol supplementation does NOT decrease LDL-C, TC, or TG. HDL-C rose significantly overall, strongest at doses ≥200mg/day and trials ≤8 weeks.",
      "source": "Zuo S, Wang G, Han Q, Xiao H, et al. 2020, Complementary Therapies in Medicine",
      "pmid": "32951713"
    },
    {
      "claim": "RCT n=87 completers, TRF-80 (420mg tocotrienol + 132mg tocopherol/day, palm) vs carotene vs placebo, 8 weeks: neither flow-mediated dilation nor any other vascular function/CVD outcome was affected, despite confirmed tocotrienol absorption. Institutionally independent (CSIRO/University of Adelaide, no industry funding).",
      "source": "Stonehouse W, Brinkworth GD, Thompson CH, Abeywardena MY 2016, Atherosclerosis",
      "pmid": "27760402"
    },
    {
      "claim": "RCT n=71, delta-tocotrienol 300mg twice daily (600mg/day) vs placebo, 24 weeks, NAFLD patients: fatty liver index and HOMA-IR both significantly improved (both primary endpoints met, p<0.001).",
      "source": "Pervez MA, Khan DA, Slehria AUR, Ijaz A 2020, Complementary Therapies in Medicine",
      "pmid": "32951743"
    },
    {
      "claim": "RCT n=100, delta-tocotrienol 300mg vs alpha-tocopherol 268mg (both twice daily), 48 weeks, NAFLD patients: both arms improved significantly on FLI/L-S ratio/HOMA-IR with NO significant difference between arms — tocotrienol was equivalent to, not better than, standard alpha-tocopherol on the primary liver endpoints.",
      "source": "Pervez MA, Khan DA, Mirza SA, Slehria AUR, Nisar U, Aamir M 2022, Complementary Therapies in Medicine",
      "pmid": "35933083"
    },
    {
      "claim": "RCT n=89, postmenopausal osteopenic women, annatto tocotrienol 430mg or 860mg/day vs placebo, 12 weeks: bone-resorption biomarkers (urine NTX, serum sRANKL, sRANKL/OPG, urine 8-OHdG) significantly decreased vs placebo — no BMD, fracture, or bone-strength outcome measured.",
      "source": "Shen CL, Yang S, Tomison MD, Romero AW, Felton CK, Mo H 2018, Osteoporosis International",
      "pmid": "29330573"
    },
    {
      "claim": "Rat feeding study: dietary alpha-tocopherol decreased alpha-tocotrienol and gamma-tocopherol tissue concentrations, inhibiting gamma-tocotrienol uptake — the mechanistic basis for the human tocopherol-attenuation finding (PMID 8614309).",
      "source": "Uchida T, Abe C, Nomura S, Ichikawa T, Ikeda S 2012, Lipids",
      "pmid": "22042641"
    }
  ],
  "products": [
    {
      "brand": "Wellness Extract",
      "product": "Eannatto Tocotrienols 300mg",
      "slug": "wellness-extract-eannatto-300mg",
      "form": "Softgel (annatto, tocopherol-free)",
      "mgPerServing": 300,
      "tocotrienolMgPerServing": 300,
      "servings": 60,
      "price": 65.99,
      "costPerServing": 1.1,
      "costPerDay": 1.1,
      "costPerMg": 0.0037,
      "sourceType": "annatto-tocopherol-free",
      "thirdParty": "Tocopherol-free per label (annatto-derived)"
    },
    {
      "brand": "Sunergetic",
      "product": "Premium Annatto Tocotrienol 300mg (DeltaGold)",
      "slug": "sunergetic-annatto-deltagold-300mg",
      "form": "Liquid capsule (annatto DeltaGold, tocopherol-free)",
      "mgPerServing": 300,
      "tocotrienolMgPerServing": 300,
      "servings": 30,
      "price": 34.95,
      "costPerServing": 1.17,
      "costPerDay": 1.17,
      "costPerMg": 0.0039,
      "sourceType": "annatto-tocopherol-free",
      "thirdParty": "DeltaGold-branded annatto tocotrienol raw material; tocopherol-free per label"
    },
    {
      "brand": "Designs for Health",
      "product": "Annatto-E 300mg (DeltaGold)",
      "slug": "designs-for-health-annatto-e-300mg",
      "form": "Softgel (annatto DeltaGold, tocopherol-free)",
      "mgPerServing": 300,
      "tocotrienolMgPerServing": 300,
      "servings": 60,
      "price": 89.99,
      "costPerServing": 1.5,
      "costPerDay": 1.5,
      "costPerMg": 0.005,
      "sourceType": "annatto-tocopherol-free",
      "thirdParty": "DeltaGold-branded annatto tocotrienol raw material (traceable ingredient source); tocopherol-free per label"
    },
    {
      "brand": "Healthy Origins",
      "product": "Tocomin SupraBio 50mg",
      "slug": "healthy-origins-tocomin-suprabio-50mg",
      "form": "Softgel (Tocomin SupraBio, palm, full-spectrum)",
      "mgPerServing": 50,
      "tocotrienolMgPerServing": 50,
      "servings": 60,
      "price": 15.99,
      "costPerServing": 0.27,
      "costPerDay": 0.27,
      "costPerMg": 0.0053,
      "sourceType": "palm-full-spectrum",
      "thirdParty": "Tocomin SupraBio-branded palm tocotrienol raw material (traceable, used in published trials); full-spectrum, contains native tocopherol"
    },
    {
      "brand": "Nutricology",
      "product": "Delta-Fraction Tocotrienols 125mg (DeltaGOLD)",
      "slug": "nutricology-delta-fraction-125mg",
      "form": "Softgel (annatto DeltaGOLD, delta-fraction, tocopherol-free)",
      "mgPerServing": 125,
      "tocotrienolMgPerServing": 125,
      "servings": 90,
      "price": 77.19,
      "costPerServing": 0.86,
      "costPerDay": 0.86,
      "costPerMg": 0.0069,
      "sourceType": "annatto-tocopherol-free",
      "thirdParty": "DeltaGOLD-branded annatto tocotrienol raw material; \"No Tocopherols\" stated on label"
    },
    {
      "brand": "NOW Foods",
      "product": "NOW Advanced Gamma E Complex",
      "slug": "now-advanced-gamma-e-complex",
      "form": "Softgel (mixed tocopherols + tocotrienols, isomer mg not disclosed)",
      "mgPerServing": 0,
      "tocotrienolMgPerServing": null,
      "servings": 120,
      "price": 22.99,
      "costPerServing": 0.19,
      "costPerDay": 0.19,
      "costPerMg": null,
      "sourceType": "mixed-tocopherol-blend",
      "thirdParty": "None claimed for tocotrienol content specifically"
    }
  ]
}