{ "name": "Seed DS-01 Alternatives: Named-Strain Probiotics by Cost per Day", "license": "https://creativecommons.org/licenses/by/4.0/", "attribution": "Verified Supplement Data, https://verifiedsupplementdata.com/probiotics/seed-alternatives/", "dateModified": "2026-09-21", "methodology": "Strain, count and serving are as each product label or listing states them; cost per day is the live Amazon price divided by servings at one serving a day. The evidence tier is the strongest study verified on PubMed for that exact strain. Seed's strain list is not reproduced because it appears on neither its Amazon listing nor an NIH DSLD label. Census figures were recomputed in two halves split by label-id parity within each population; figures that did not agree within tolerance are not published.", "benchmark": { "name": "Seed DS-01 Daily Synbiotic (53.6B AFU, 60ct)", "brand": "Seed", "slug": "seed-ds01-daily-synbiotic", "strainNamedOnLabel": "24 strains, not named on the Amazon listing; not filed with the NIH DSLD", "countPerServing": "53.6 billion AFU", "servingSize": "2 capsules", "servingsPerContainer": 30, "priceUsd": 59.99, "priceVerifiedOn": "2026-09-20", "costPerDayUsd": 2, "evidenceTier": "Brand trial, not on file", "outcomeTested": "listing claims a bloating and gas trial in healthy adults; uncited, not verified here", "evidenceSource": "Amazon listing, Creators API", "certification": "None", "nihDsldId": null, "availability": "ok", "note": "AFU (active fluorescent units) is a flow-cytometry viable-cell count, not CFU" }, "alternatives": [ { "name": "Schiff Digestive Advantage Daily Probiotic (2B CFU BC30, 60ct)", "brand": "Schiff", "slug": "schiff-digestive-advantage", "strainNamedOnLabel": "Bacillus coagulans GBI-30, 6086", "countPerServing": "2 billion CFU", "servingSize": "1 capsule", "servingsPerContainer": 80, "priceUsd": 24, "priceVerifiedOn": "2026-09-20", "costPerDayUsd": 0.3, "evidenceTier": "Preliminary RCT", "outcomeTested": "IBS pain and bloating, 44 patients, within-group analysis", "evidenceSource": "Hun 2009, PMID 19332970", "certification": "None", "nihDsldId": null, "availability": "ok" }, { "name": "Culturelle Daily Probiotic (10B CFU, 30ct)", "brand": "Culturelle", "slug": "culturelle-daily-probiotic", "strainNamedOnLabel": "Lactobacillus rhamnosus GG", "countPerServing": "10 billion CFU", "servingSize": "1 capsule", "servingsPerContainer": 30, "priceUsd": 17.47, "priceVerifiedOn": "2026-09-20", "costPerDayUsd": 0.582, "evidenceTier": "Cochrane / meta-analysis", "outcomeTested": "antibiotic-associated diarrhea, 8% vs 19% across 23 pediatric trials (RR 0.46); adults+children RR 0.58, NNT 13", "evidenceSource": "Goldenberg 2015, PMID 26695080; Hempel 2012, PMID 22570464", "certification": "None", "nihDsldId": null, "availability": "ok" }, { "name": "Culturelle Kids Purely Probiotics Chewables (30 tablets)", "brand": "Culturelle", "slug": "culturelle-kids-chewables", "strainNamedOnLabel": "Lactobacillus rhamnosus GG", "countPerServing": "5 billion CFU L. rhamnosus GG", "servingSize": "1 chewable", "servingsPerContainer": 30, "priceUsd": 20.48, "priceVerifiedOn": "2026-09-18", "costPerDayUsd": 0.683, "evidenceTier": "Cochrane / meta-analysis", "outcomeTested": "pediatric antibiotic-associated diarrhea", "evidenceSource": "Goldenberg 2015, PMID 26695080", "certification": "None stated", "nihDsldId": "250912", "availability": "ok" }, { "name": "BioGaia Protectis Baby Drops (5 mL, 25 doses)", "brand": "BioGaia", "slug": "biogaia-protectis-baby-drops", "strainNamedOnLabel": "Lactobacillus reuteri DSM 17938", "countPerServing": "0.1 billion CFU L. reuteri DSM 17938", "servingSize": "5 drops", "servingsPerContainer": 25, "priceUsd": 17.58, "priceVerifiedOn": "2026-09-18", "costPerDayUsd": 0.703, "evidenceTier": "Meta-analysis, infants", "outcomeTested": "infant colic, -25.4 min crying/fussing at day 21 across 4 trials (345 infants); NNT 2.6 breastfed", "evidenceSource": "Sung 2018, PMID 29279326", "certification": "None stated", "nihDsldId": "311013", "availability": "ok" }, { "name": "Florastor Daily Probiotic (250mg S. boulardii, 30ct)", "brand": "Florastor", "slug": "florastor-daily-probiotic", "strainNamedOnLabel": "Saccharomyces boulardii CNCM I-745", "countPerServing": "250 mg", "servingSize": "1 capsule", "servingsPerContainer": 30, "priceUsd": 23.99, "priceVerifiedOn": "2026-09-20", "costPerDayUsd": 0.8, "evidenceTier": "Cochrane / meta-analysis", "outcomeTested": "antibiotic-associated diarrhea 18.7% to 8.5% across 21 trials (RR 0.47, NNT 10); traveler's diarrhea", "evidenceSource": "Szajewska 2015, PMID 26216624; McFarland 2007, PMID 17298915", "certification": "None", "nihDsldId": null, "availability": "ok" }, { "name": "Florastor Kids Probiotic Powder (20 sticks)", "brand": "Florastor", "slug": "florastor-kids-powder-sticks", "strainNamedOnLabel": "Saccharomyces boulardii CNCM I-745", "countPerServing": "250 mg Saccharomyces boulardii CNCM I-745", "servingSize": "1 stick", "servingsPerContainer": 20, "priceUsd": 18.59, "priceVerifiedOn": "2026-09-18", "costPerDayUsd": 0.93, "evidenceTier": "Cochrane / meta-analysis", "outcomeTested": "pediatric antibiotic-associated diarrhea", "evidenceSource": "Szajewska 2015, PMID 26216624", "certification": "None stated", "nihDsldId": "206738", "availability": "ok" }, { "name": "Visbiome High Potency Probiotic (112.5B CFU, 60ct)", "brand": "Visbiome", "slug": "visbiome-high-potency", "strainNamedOnLabel": "De Simone formulation (8 strains)", "countPerServing": "112.5 billion CFU", "servingSize": "1 capsule", "servingsPerContainer": 60, "priceUsd": 73.95, "priceVerifiedOn": "2026-09-20", "costPerDayUsd": 1.233, "evidenceTier": "Large RCT + guideline", "outcomeTested": "ulcerative colitis, 63.1% vs 40.8% response at 3,600 billion CFU/day (144 patients); AGA conditional recommendation for pouchitis", "evidenceSource": "Tursi 2010, PMID 20517305; Su 2020, PMID 32531291", "certification": "None", "nihDsldId": null, "availability": "ok" } ], "notRanked": [ { "strain": "Bifidobacterium longum subsp. infantis 35624", "reason": "the product carrying it currently has no buyable Amazon listing; no substitute is offered for a strain-specific result", "source": "Whorwell 2006, PMID 16863564" } ], "labelCensus": { "source": "NIH Dietary Supplement Label Database (DSLD) v9", "sourceUrl": "https://dsld.od.nih.gov/", "retrievedOn": "2026-09-16", "labelsRetrieved": 900, "labelsAnalysed": 896, "generalLabels": 819, "womenMarketedLabels": 77, "general": { "structuredCfuQuantityPct": 8.8, "medianSpeciesNamed": 5, "namingLCrispatusPct": 0.5 }, "women": { "proprietaryBlendRowPct": 93.5, "namingGr1Rc14Pct": 14.3, "namingLCrispatusPct": 2.6 }, "validation": { "method": "split-half by DSLD id parity within population", "checked": 9, "held": 6, "failed": [ "women's labels with a structured CFU quantity", "women's labels adding cranberry / D-mannose", "median species named, women's labels" ] }, "notPublished": [ "women's labels with a structured CFU quantity", "women's labels adding cranberry / D-mannose", "median species named, women's labels", "share of general labels naming L. rhamnosus GG (computed, not split-half checked)" ] } }