{
  "dataset": "nmn-cost-by-brand",
  "title": "NMN Supplements Compared — cost per mg, dose tier, and purity/third-party-testing disclosure",
  "sourcePage": "https://verifiedsupplementdata.com/nmn/best-overall/",
  "license": "CC-BY-4.0",
  "licenseUrl": "https://creativecommons.org/licenses/by/4.0/",
  "attribution": "Verified Supplement Data (2026), NMN Cost Comparison",
  "dateModified": "2026-07-18",
  "methodology": "All six products here disclose NMN mg directly on the label, so cost per mg is a computable comparison: costPerMg = price / (servings x mg per serving). \"verdict\" tags dose tier against the trial evidence: underdosed (below the 250 mg lowest single-trial dose), studied (250-999 mg, within the Liao 2021 / Yi 2023 dose-ranging range), high-dose (1000 mg+, at or near Liao's 1200 mg high arm and the 1250 mg/day safety ceiling Fukamizu 2022 tested for 4 WEEKS ONLY — not established as safe long-term). \"purityTier\" is the PRIMARY ranking axis on the best-overall page, not price: named-material (a branded, traceable raw material such as Uthever, used in published trials), third-party-claimed (brand states third-party testing, not independently verified by us), claim-only (a purity percentage claim with no third-party-testing disclosure). This purity emphasis exists because ChromaDex's 2021 industry test of 22 top-selling Amazon NMN brands found only 14% met their label claim, 64% had under 1% of claimed NMN, and 14% had ZERO NMN — industry testing, not a peer-reviewed PMID, cited with lower evidentiary weight than the trial data below but directly relevant to why testing disclosure matters more than the milligram number. EVIDENCE CONTEXT (short-term human RCTs only, no lifespan/anti-aging claim implied or supported): Yoshino 2021 (PMID 33888596, n=25, 250 mg/day, insulin-sensitivity RCT, NIH-funded) — always disclose its published baseline hepatic-lipid imbalance critique (6.3% vs 14.8%, p=0.003). Chen 2024 (PMID 39531138) is a systematic review/meta-analysis of 8 RCTs finding NO significant glucose/lipid benefit — the essential honest counterweight. Fukamizu 2022 (PMID 36002548) is the key safety RCT, 1250 mg/day x 4 weeks, no severe adverse events, but no long-term human safety data exists at any dose. Regulatory note: NMN was excluded from the US dietary-supplement definition in Nov 2022, delisted from Amazon by March 2023, and FDA reversed course in Sept 2025, confirming NMN is NOT excluded — Amazon relisted within weeks. This statement has not been evaluated by the FDA; these products are not intended to diagnose, treat, cure, or prevent any disease.",
  "headline": {
    "productsCompared": 6,
    "underdosed": 1,
    "studied": 4,
    "highDose": 1,
    "lowDoseMg": 300,
    "mostCommonTrialMg": 250,
    "highDoseMg": 1200,
    "safetyCeilingMg": 1250,
    "cheapestPerMg": 0.0004,
    "cheapestPerMgBrand": "Toniiq",
    "cheapestAtLowDoseBrand": "Toniiq",
    "cheapestWithPurityDisclosureBrand": "Toniiq",
    "note": "The cheapest cost per mg overall is a 1200 mg high-dose product, close to (not beyond) the 1250 mg/4-week-only safety ceiling — not automatically the best buy for someone wanting a trial-matched low dose. Ranked by purity/third-party-testing disclosure FIRST on the best-overall page, price second."
  },
  "columns": [
    "brand",
    "product",
    "slug",
    "form",
    "mgPerServing",
    "servings",
    "price",
    "costPerServing",
    "costPerMg",
    "verdict",
    "purityTier",
    "thirdParty"
  ],
  "units": {
    "mgPerServing": "mg NMN",
    "price": "USD",
    "costPerServing": "USD/serving",
    "costPerMg": "USD per mg of NMN"
  },
  "citations": [
    {
      "claim": "RCT n=25 postmenopausal women, 250 mg/day 10 weeks: insulin-stimulated glucose disposal and muscle insulin signaling improved vs placebo; NIH-funded. Published Comment found NMN group had significantly lower baseline hepatic lipid content (6.3% vs 14.8%, p=0.003) — a randomization imbalance that undercuts the headline result.",
      "source": "Yoshino M, Imai S, et al. 2021, Science",
      "pmid": "33888596"
    },
    {
      "claim": "RCT n=48 recreationally-trained runners, 300/600/1200 mg/day 6 weeks: aerobic capacity improved dose-dependently. No industry funding disclosed.",
      "source": "Liao B, et al. 2021, J Int Soc Sports Nutr",
      "pmid": "34238308"
    },
    {
      "claim": "RCT n=80 healthy middle-aged adults, 300/600/900 mg/day 60 days: 6-minute walk distance rose significantly in all dose groups; 300 mg was the weakest responder. Co-authors affiliated with Abinopharm (NMN ingredient company).",
      "source": "Yi L, et al. 2023, GeroScience",
      "pmid": "36482258"
    },
    {
      "claim": "Safety RCT n=31, single-dose escalation + 1250 mg/day x 4 weeks: no severe adverse events. No long-term (6mo+) human safety data exists at any dose.",
      "source": "Fukamizu Y, et al. 2022, Scientific Reports",
      "pmid": "36002548"
    },
    {
      "claim": "Systematic review + meta-analysis of 8 RCTs (250-2000 mg/day): NMN did NOT show significant positive effects on glucose control or lipid profile in the pooled analysis.",
      "source": "Chen K, et al. 2024, Current Diabetes Reports",
      "pmid": "39531138"
    }
  ],
  "products": [
    {
      "brand": "Toniiq",
      "product": "NMN 1200 mg",
      "slug": "toniiq-nmn-1200mg",
      "form": "Capsule (stabilized NMN)",
      "mgPerServing": 1200,
      "servings": 60,
      "price": 29.97,
      "costPerServing": 0.5,
      "costPerMg": 0.0004,
      "verdict": "high-dose",
      "thirdParty": "Third-party tested (brand claim); 98% purity claimed",
      "purityTier": "third-party-claimed"
    },
    {
      "brand": "Genex Formulas",
      "product": "NMN 500 mg",
      "slug": "genex-formulas-nmn-500mg",
      "form": "Capsule",
      "mgPerServing": 500,
      "servings": 60,
      "price": 29.99,
      "costPerServing": 0.5,
      "costPerMg": 0.001,
      "verdict": "studied",
      "thirdParty": "GMP-certified facility (brand claim); 99% purity claim, no third-party testing disclosed",
      "purityTier": "claim-only"
    },
    {
      "brand": "Toniiq",
      "product": "Stabilized NMN 300 mg",
      "slug": "toniiq-nmn-300mg",
      "form": "Capsule (stabilized NMN)",
      "mgPerServing": 300,
      "servings": 60,
      "price": 19.97,
      "costPerServing": 0.33,
      "costPerMg": 0.0011,
      "verdict": "studied",
      "thirdParty": "Third-party tested (brand claim); 98% purity claimed",
      "purityTier": "third-party-claimed"
    },
    {
      "brand": "ProHealth Longevity",
      "product": "NMN Pro 1000 (Uthever)",
      "slug": "prohealth-nmn-pro-1000-uthever",
      "form": "Capsule (Uthever NMN)",
      "mgPerServing": 1000,
      "servings": 60,
      "price": 64.95,
      "costPerServing": 1.08,
      "costPerMg": 0.0011,
      "verdict": "studied",
      "thirdParty": "Uthever branded raw material (traceable, used in published human trials); triple lab-tested (brand claim)",
      "purityTier": "named-material"
    },
    {
      "brand": "Renue By Science",
      "product": "NMN Powder",
      "slug": "renue-by-science-nmn-powder",
      "form": "Powder",
      "mgPerServing": 500,
      "servings": 57,
      "price": 54.95,
      "costPerServing": 0.96,
      "costPerMg": 0.0019,
      "verdict": "studied",
      "thirdParty": "Third-party tested (brand claim); brand publishes its own competitor-testing program (disclosed as a brand claim, not independently confirmed by us)",
      "purityTier": "third-party-claimed"
    },
    {
      "brand": "Double Wood",
      "product": "NMN 125 mg",
      "slug": "double-wood-nmn-125mg",
      "form": "Capsule",
      "mgPerServing": 125,
      "servings": 60,
      "price": 32.95,
      "costPerServing": 0.55,
      "costPerMg": 0.0044,
      "verdict": "underdosed",
      "thirdParty": "99% purity claim (brand-stated, no third-party testing disclosed)",
      "purityTier": "claim-only"
    }
  ]
}