{ "dataset": "grape-seed-extract-cost-by-brand", "title": "Grape Seed Extract (GSE / OPC) Supplements Compared — OPC standardization disclosure, dose vs trial range, and cost per mg", "sourcePage": "https://verifiedsupplementdata.com/grape-seed-extract/best-overall/", "license": "CC-BY-4.0", "licenseUrl": "https://creativecommons.org/licenses/by/4.0/", "attribution": "Verified Supplement Data (2026), Grape Seed Extract Cost Comparison", "dateModified": "2026-07-19", "methodology": "4 of 6 tracked grape seed extract products disclose an OPC/proanthocyanidin standardization percentage on the label (90-95%) — those products are ranked first, by cost per day, because standardization (not raw cost per mg alone) is the primary honest ranking axis for this ingredient: the blood-pressure trials tested standardized proanthocyanidin-rich extracts, and an unstandardized \"grape seed extract Xmg\" label cannot be verified to match that material. costPerMg = price / (servings x mg per serving), computed on total extract weight. \"verdict\": standardized (label prints an OPC/proanthocyanidin %), undisclosed (label states only vague \"bioflavonoids\" with no OPC/proanthocyanidin % — a real transparency gap, flagged not ranked as a top pick), combo-non-pure (multi-ingredient product bundling GSE with other actives; isolated GSE mg not disclosed, excluded from the cost-per-mg ranking). EVIDENCE CONTEXT (real but modest effect, YMYL category — not a hypertension-drug claim): three independent meta-analyses (Feringa 2011 PMID 21802563, Zhang 2016 PMID 27537554, Foshati 2022 PMID 34798267) converge on a small, real blood-pressure-lowering effect, meaningfully larger in younger, obese, or metabolic-syndrome subgroups and smaller or absent otherwise — but a well-designed single RCT (Ras 2013, PMID 23702253, 300mg/day, ambulatory BP) found no statistically significant effect. GSE has documented in vitro antiplatelet/anticoagulant activity (Bijak 2019, PMID 30621248) that is mechanistic, not confirmed in human dosing trials — anyone on blood thinners or facing surgery should talk to a clinician before use. This statement has not been evaluated by the FDA; these products are not intended to diagnose, treat, cure, or prevent any disease.", "headline": { "productsCompared": 6, "standardizedDisclosed": 4, "standardizedPickBrand": "Nutricost", "standardizedOpcPct": 95, "undisclosedBrand": "Puritan's Pride", "comboBrand": "Life Extension", "typicalDoseRangeMg": [ 150, 300 ], "highestPooledTrialDoseMg": 800, "nullResultDoseMg": 300, "note": "The standardized products (90-95% OPCs disclosed) are the headline recommendations, ranked by cost per day. The undisclosed-standardization product and the multi-ingredient combo product are flagged separately, not ranked as top picks." }, "columns": [ "brand", "product", "slug", "form", "mgPerServing", "opcPct", "activeOpcMg", "servings", "price", "costPerServing", "costPerMg", "verdict", "certification" ], "units": { "mgPerServing": "mg GSE extract", "activeOpcMg": "mg OPCs/proanthocyanidins (where disclosed)", "price": "USD", "costPerServing": "USD/serving", "costPerMg": "USD per mg of extract" }, "citations": [ { "claim": "Meta-analysis of 9 RCTs (N=390): SBP significantly lowered (WMD -1.54 mmHg), no significant effect on DBP, lipids, or CRP.", "source": "Feringa HH, et al. 2011, Journal of the American Dietetic Association", "pmid": "21802563" }, { "claim": "Meta-analysis of 16 RCTs (N=810): SBP WMD -6.08 mmHg, DBP WMD -2.80 mmHg, significantly larger effect in younger, obese, and metabolic-syndrome subgroups.", "source": "Zhang H, et al. 2016, Medicine (Baltimore)", "pmid": "27537554" }, { "claim": "Meta-analysis of 19 trials: DBP significantly reduced (WMD -2.20 mmHg), but no significant effect on SBP or flow-mediated dilation, with high heterogeneity (I²=88-97%).", "source": "Foshati S, et al. 2022, Pharmacological Research", "pmid": "34798267" }, { "claim": "Double-blind RCT (n=70), GSE 300mg/day for 8 weeks: did NOT significantly lower 24-hour ambulatory blood pressure (-3.0 mmHg SBP, CI crosses zero).", "source": "Ras RT, et al. 2013, British Journal of Nutrition", "pmid": "23702253" }, { "claim": "In vitro study: GSE reduced ADP-induced platelet aggregation and affected coagulation/thromboelastometry assays in a dose-dependent way — mechanistic basis for the antiplatelet/blood-thinner caution, not a human bleeding-outcome trial.", "source": "Bijak M, et al. 2019, Nutrients", "pmid": "30621248" } ], "products": [ { "brand": "Nutricost", "product": "Grape Seed Extract 400mg (95% Proanthocyanidins, 70:1 Extract)", "slug": "nutricost-grape-seed-extract-400mg", "form": "Capsule (70:1 extract)", "mgPerServing": 400, "opcPct": 95, "activeOpcMg": 380, "servings": 240, "price": 19.95, "costPerServing": 0.08, "costPerMg": 0.0002, "verdict": "standardized", "note": "95% proanthocyanidins/OPCs disclosed on label, 70:1 extract ratio stated — the highest disclosed standardization in this comparison, at the best cost per day among standardized products.", "certification": "None claimed" }, { "brand": "Bronson", "product": "Grape Seed Extract 400mg (95% OPCs)", "slug": "bronson-grape-seed-extract-400mg", "form": "Capsule", "mgPerServing": 400, "opcPct": 95, "activeOpcMg": 380, "servings": 90, "price": 9.99, "costPerServing": 0.11, "costPerMg": 0.0003, "verdict": "standardized", "note": "95% proanthocyanidins/OPCs disclosed on label — the cheapest well-standardized option in this comparison.", "certification": "None claimed" }, { "brand": "NOW Foods", "product": "Grape Seed 100mg (90% Standardized, with Vitamin C)", "slug": "now-foods-grape-seed-100mg", "form": "Veg capsule", "mgPerServing": 100, "opcPct": 90, "activeOpcMg": 90, "servings": 200, "price": 24.95, "costPerServing": 0.12, "costPerMg": 0.0012, "verdict": "standardized", "note": "Label states \"minimum of 90% polyphenols\" — disclosed standardization, at a 100mg dose closest to the low end of the typical trial range, from a reputable widely-available brand.", "certification": "cGMP; widely recognized brand" }, { "brand": "Doctor's Recipes", "product": "Grape Seed Extract 500mg (95% OPCs)", "slug": "doctors-recipes-grape-seed-extract-500mg", "form": "Capsule", "mgPerServing": 500, "opcPct": 95, "activeOpcMg": 475, "servings": 60, "price": 9.99, "costPerServing": 0.17, "costPerMg": 0.0003, "verdict": "standardized", "note": "95% proanthocyanidins/OPCs disclosed on label — the highest disclosed-standardization dose in this comparison, above the typical 150-300mg/day trial range.", "certification": "None claimed" }, { "brand": "Puritan's Pride", "product": "Grapeseed Extract 200mg (2 Capsules/Day)", "slug": "puritans-pride-grapeseed-extract-200mg", "form": "Capsule", "mgPerServing": 400, "opcPct": null, "activeOpcMg": null, "servings": 60, "price": 8.9, "costPerServing": 0.15, "costPerMg": 0.0004, "verdict": "undisclosed", "note": "Label states only \"50mg bioflavonoids\" — no OPC/proanthocyanidin percentage disclosed. Standardization is unverifiable against the trial-tested material at any price.", "certification": "None claimed" }, { "brand": "Life Extension", "product": "Grapeseed Extract with Vitamin C, Resveratrol & Calcium", "slug": "life-extension-grapeseed-vitc-resveratrol-60ct", "form": "Capsule (grape seed extract + vitamin C + resveratrol + calcium combo)", "mgPerServing": 100, "opcPct": null, "activeOpcMg": null, "servings": 60, "price": 23, "costPerServing": 0.38, "costPerMg": 0.0038, "verdict": "combo-non-pure", "note": "The isolated grape seed extract mg is not disclosed on the label — bundled with vitamin C, resveratrol, and calcium, each with its own separate evidence base. Not a pure/isolated GSE product.", "certification": "Combo product: grape seed extract + vitamin C + resveratrol + calcium — NOT a pure GSE product" } ] }