{ "name": "Verified Supplement Data — Condition × Ingredient Evidence Crosswalk v1", "description": "Which supplement is linked to which condition/use, with relationship type, evidence grade where graded, dose-for-use, supporting PubMed IDs, and the source (dataset or on-site page). Built only from PMID-bearing structured data and researched on-site pages — no invented pairs or grades.", "license": "CC BY 4.0", "source": "verifiedsupplementdata.com", "relationship_types": { "deficiency-symptom": "correcting a deficiency of this nutrient improves the symptom (grade = evidence_strength)", "therapeutic-dose": "studied dose of this ingredient for this use", "reviewed-on-site": "pair has a researched, PMID-cited page on the site" }, "rows": [ { "ingredient_id": "ashwagandha", "ingredient": "Ashwagandha", "condition_id": "anxiety", "condition": "Anxiety", "canonical_condition_id": "anxiety", "canonical_condition": "Anxiety", "relationship": "therapeutic-dose", "evidence": "", "dose": "300-600 mg KSM-66", "pmids": "31517876", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "ashwagandha", "ingredient": "Ashwagandha", "condition_id": "anxiety-depression", "condition": "Anxiety Depression", "canonical_condition_id": "anxiety-depression", "canonical_condition": "Anxiety Depression", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "28654669; 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32818573", "source": "site-page", "source_url": "/ashwagandha/for-sleep/" }, { "ingredient_id": "ashwagandha", "ingredient": "Ashwagandha", "condition_id": "stress", "condition": "Stress", "canonical_condition_id": "stress", "canonical_condition": "Stress", "relationship": "therapeutic-dose", "evidence": "", "dose": "300-600 mg KSM-66 extract", "pmids": "23439798", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "ashwagandha", "ingredient": "Ashwagandha", "condition_id": "stress", "condition": "Stress", "canonical_condition_id": "stress", "canonical_condition": "Stress", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "23439798; 28445426; 31623400", "source": "condition-protocol", "source_url": "/conditions/stress/" }, { "ingredient_id": "berberine", "ingredient": "Berberine", "condition_id": "blood-sugar", "condition": "Blood Sugar", "canonical_condition_id": "blood-sugar", "canonical_condition": "Blood Sugar", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "38016844; 34956436; 18397984", "source": "site-page", "source_url": "/berberine/for-blood-sugar/" }, { "ingredient_id": "berberine", "ingredient": "Berberine", "condition_id": "pcos", "condition": "Pcos", "canonical_condition_id": "pcos", "canonical_condition": "Pcos", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "", "source": "condition-protocol", "source_url": "/conditions/pcos/" }, { "ingredient_id": "biotin", "ingredient": "Biotin", "condition_id": "hair-growth", "condition": "Hair Growth", "canonical_condition_id": "hair-health", "canonical_condition": "Hair Health", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "28879195", "source": "site-page", "source_url": "/biotin/for-hair-growth/" }, { "ingredient_id": "biotin", "ingredient": "Biotin", "condition_id": "hair-maintenance", "condition": "Hair Maintenance", "canonical_condition_id": "hair-health", "canonical_condition": "Hair Health", "relationship": "therapeutic-dose", "evidence": "", "dose": "2500-5000 mcg", "pmids": "", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "biotin", "ingredient": "Biotin", "condition_id": "nails", "condition": "Nails", "canonical_condition_id": "nails", "canonical_condition": "Nails", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "8477615; 28879195", "source": "site-page", "source_url": "/biotin/for-nails/" }, { "ingredient_id": "calcium", "ingredient": "Calcium", "condition_id": "bones-osteoporosis", "condition": "Bones Osteoporosis", "canonical_condition_id": "osteoporosis", "canonical_condition": "Osteoporosis / Bone Health", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "29279934; 26510847; 21505219", "source": "site-page", "source_url": "/calcium/for-bones-osteoporosis/" }, { "ingredient_id": "calcium", "ingredient": "Calcium", "condition_id": "muscle-cramps", "condition": "Muscle Cramps", "canonical_condition_id": "muscle-cramps", "canonical_condition": "Muscle Cramps", "relationship": "deficiency-symptom", "evidence": "moderate", "dose": "", "pmids": "", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/leg-cramps-at-night/" }, { "ingredient_id": "calcium", "ingredient": "Calcium", "condition_id": "osteoporosis", "condition": "Osteoporosis", "canonical_condition_id": "osteoporosis", "canonical_condition": "Osteoporosis / Bone Health", "relationship": "therapeutic-dose", "evidence": "", "dose": "1000-1200 mg", "pmids": "", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "calcium", "ingredient": "Calcium", "condition_id": "women-over-50", "condition": "Women Over 50", "canonical_condition_id": "women-over-50", "canonical_condition": "Women Over 50", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "29279934; 21505219", "source": "site-page", "source_url": "/calcium/for-women-over-50/" }, { "ingredient_id": "chondroitin", "ingredient": "Chondroitin", "condition_id": "joint-pain", "condition": "Joint Pain", "canonical_condition_id": "joint-pain", "canonical_condition": "Joint Pain", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "", "source": "condition-protocol", "source_url": "/conditions/joint-pain/" }, { "ingredient_id": "chondroitin", "ingredient": "Chondroitin", "condition_id": "osteoarthritis", "condition": "Osteoarthritis", "canonical_condition_id": "osteoarthritis", "canonical_condition": "Osteoarthritis", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "25589511; 30575881", "source": "site-page", "source_url": "/chondroitin/for-osteoarthritis/" }, { "ingredient_id": "collagen", "ingredient": "Collagen", "condition_id": "joint-pain", "condition": "Joint Pain", "canonical_condition_id": "joint-pain", "canonical_condition": "Joint Pain", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "", "source": "condition-protocol", "source_url": "/conditions/joint-pain/" }, { "ingredient_id": "collagen", "ingredient": "Collagen", "condition_id": "skin", "condition": "Skin", "canonical_condition_id": "skin", "canonical_condition": "Skin", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "23949208; 37432180; 24401291; 31627309", "source": "site-page", "source_url": "/collagen/for-skin/" }, { "ingredient_id": "coq10", "ingredient": "CoQ10", "condition_id": "afternoon-energy-crash", "condition": "Afternoon Energy Crash", "canonical_condition_id": "fatigue", "canonical_condition": "Fatigue & Low Energy", "relationship": "deficiency-symptom", "evidence": "moderate", "dose": "", "pmids": "", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/afternoon-crash/" }, { "ingredient_id": "coq10", "ingredient": "CoQ10", "condition_id": "always-tired", "condition": "Always Tired", "canonical_condition_id": "fatigue", "canonical_condition": "Fatigue & Low Energy", "relationship": "deficiency-symptom", "evidence": "moderate", "dose": "", "pmids": "", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/always-tired/" }, { "ingredient_id": "coq10", "ingredient": "CoQ10", "condition_id": "fatigue", "condition": "Fatigue", "canonical_condition_id": "fatigue", "canonical_condition": "Fatigue & Low Energy", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "22777991; 25282031; 28925645", "source": "condition-protocol", "source_url": "/conditions/fatigue/" }, { "ingredient_id": "coq10", "ingredient": "CoQ10", "condition_id": "heart-failure", "condition": "Heart Failure", "canonical_condition_id": "heart-failure", "canonical_condition": "Heart Failure", "relationship": "therapeutic-dose", "evidence": "", "dose": "200-400 mg", "pmids": "", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "coq10", "ingredient": "CoQ10", "condition_id": "heart-palpitations", "condition": "Heart Palpitations", "canonical_condition_id": "heart-palpitations", "canonical_condition": "Heart Palpitations", "relationship": "deficiency-symptom", "evidence": "moderate", "dose": "", "pmids": "", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/heart-palpitations/" }, { "ingredient_id": "coq10", "ingredient": "CoQ10", "condition_id": "statin-support", "condition": "Statin Support", "canonical_condition_id": "statin-support", "canonical_condition": "Statin Support", "relationship": "therapeutic-dose", "evidence": "", "dose": "100-200 mg", "pmids": "30371340", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "coq10", "ingredient": "CoQ10", "condition_id": "statins", "condition": "Statins", "canonical_condition_id": "statins", "canonical_condition": "Statins", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "30371340; 32179207; 25282031", "source": "site-page", "source_url": "/coq10/for-statins/" }, { "ingredient_id": "creatine", "ingredient": "Creatine", "condition_id": "brain", "condition": "Brain", "canonical_condition_id": "brain", "canonical_condition": "Brain", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "35984306; 38418482; 39070254; 28615996", "source": "site-page", "source_url": "/creatine/for-brain/" }, { "ingredient_id": "creatine", "ingredient": "Creatine", "condition_id": "muscle-building", "condition": "Muscle Building", "canonical_condition_id": "muscle-building", "canonical_condition": "Muscle Building", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "37432300; 28615996; 34199420; 33557850", "source": "site-page", "source_url": "/creatine/best-for-muscle-building/" }, { "ingredient_id": "creatine", "ingredient": "Creatine", "condition_id": "women", "condition": "Women", "canonical_condition_id": "women", "canonical_condition": "Women", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "28615996; 42141930; 40371844; 35984306; 39070254", "source": "site-page", "source_url": "/creatine/best-for-women/" }, { "ingredient_id": "curcumin", "ingredient": "Curcumin", "condition_id": "joint-pain", "condition": "Joint Pain", "canonical_condition_id": "joint-pain", "canonical_condition": "Joint Pain", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "38036015; 33500785; 36804260", "source": "site-page", "source_url": "/curcumin/for-joint-pain/" }, { "ingredient_id": "electrolytes", "ingredient": "Electrolytes", "condition_id": "athletic", "condition": "Athletic", "canonical_condition_id": "athletic", "canonical_condition": "Athletic", "relationship": "therapeutic-dose", "evidence": "", "dose": "500-1500 mg sodium per hour of exercise", "pmids": "", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "electrolytes", "ingredient": "Electrolytes", "condition_id": "fasting-keto", "condition": "Fasting Keto", "canonical_condition_id": "fasting-keto", "canonical_condition": "Fasting Keto", "relationship": "therapeutic-dose", "evidence": "", "dose": "2000-5000 mg sodium per day", "pmids": "", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "folate", "ingredient": "Folate / Methylfolate", "condition_id": "always-tired", "condition": "Always Tired", "canonical_condition_id": "fatigue", "canonical_condition": "Fatigue & Low Energy", "relationship": "deficiency-symptom", "evidence": "moderate", "dose": "", "pmids": "", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/always-tired/" }, { "ingredient_id": "folate", "ingredient": "Folate / Methylfolate", "condition_id": "depression", "condition": "Depression", "canonical_condition_id": "depression", "canonical_condition": "Depression", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "24813065; 27035404", "source": "site-page", "source_url": "/methylfolate/for-depression/" }, { "ingredient_id": "folate", "ingredient": "Folate / Methylfolate", "condition_id": "feeling-depressed", "condition": "Feeling Depressed", "canonical_condition_id": "depression", "canonical_condition": "Depression", "relationship": "deficiency-symptom", "evidence": "strong", "dose": "", "pmids": "22950138", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/feeling-depressed/" }, { "ingredient_id": "glucosamine", "ingredient": "Glucosamine", "condition_id": "joint-pain", "condition": "Joint Pain", "canonical_condition_id": "joint-pain", "canonical_condition": "Joint Pain", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "", "source": "condition-protocol", "source_url": "/conditions/joint-pain/" }, { "ingredient_id": "glucosamine", "ingredient": "Glucosamine", "condition_id": "osteoarthritis", "condition": "Osteoarthritis", "canonical_condition_id": "osteoarthritis", "canonical_condition": "Osteoarthritis", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "20525840; 15846645; 25589511", "source": "site-page", "source_url": "/glucosamine/for-osteoarthritis/" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "afternoon-energy-crash", "condition": "Afternoon Energy Crash", "canonical_condition_id": "fatigue", "canonical_condition": "Fatigue & Low Energy", "relationship": "deficiency-symptom", "evidence": "moderate", "dose": "", "pmids": "", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/afternoon-crash/" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "always-tired", "condition": "Always Tired", "canonical_condition_id": "fatigue", "canonical_condition": "Fatigue & Low Energy", "relationship": "deficiency-symptom", "evidence": "strong", "dose": "", "pmids": "17344500", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/always-tired/" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "anemia-low-ferritin", "condition": "Anemia Low Ferritin", "canonical_condition_id": "anemia-low-ferritin", "canonical_condition": "Anemia Low Ferritin", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "29032957; 37979057; 38864796", "source": "site-page", "source_url": "/iron/for-anemia-low-ferritin/" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "brain-fog", "condition": "Brain Fog", "canonical_condition_id": "brain-fog", "canonical_condition": "Brain Fog", "relationship": "deficiency-symptom", "evidence": "moderate", "dose": "", "pmids": "17344500", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/brain-fog/" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "deficiency", "condition": "Deficiency", "canonical_condition_id": "deficiency", "canonical_condition": "Deficiency", "relationship": "therapeutic-dose", "evidence": "", "dose": "25-65 mg elemental", "pmids": "", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "fatigue", "condition": "Fatigue", "canonical_condition_id": "fatigue", "canonical_condition": "Fatigue & Low Energy", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "22777991; 25282031; 28925645", "source": "condition-protocol", "source_url": "/conditions/fatigue/" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "hair-falling-out", "condition": "Hair Falling Out", "canonical_condition_id": "hair-health", "canonical_condition": "Hair Health", "relationship": "deficiency-symptom", "evidence": "strong", "dose": "", "pmids": "", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/hair-falling-out/" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "heavy-periods", "condition": "Heavy Periods", "canonical_condition_id": "heavy-periods", "canonical_condition": "Heavy Periods", "relationship": "deficiency-symptom", "evidence": "strong", "dose": "", "pmids": "", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/heavy-periods/" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "pregnancy", "condition": "Pregnancy", "canonical_condition_id": "pregnancy", "canonical_condition": "Pregnancy", "relationship": "therapeutic-dose", "evidence": "", "dose": "27-60 mg elemental", "pmids": "", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "restless-legs", "condition": "Restless Legs", "canonical_condition_id": "restless-legs", "canonical_condition": "Restless Legs", "relationship": "deficiency-symptom", "evidence": "strong", "dose": "", "pmids": "17557425", "source": "matrix.deficiency_symptoms", "source_url": "/symptoms/restless-legs/" }, { "ingredient_id": "iron", "ingredient": "Iron", "condition_id": "women", "condition": "Women", "canonical_condition_id": "women", "canonical_condition": "Women", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "38042684; 29032957", "source": "site-page", "source_url": "/iron/for-women/" }, { "ingredient_id": "l-theanine", "ingredient": "L-Theanine", "condition_id": "anxiety", "condition": "Anxiety", "canonical_condition_id": "anxiety", "canonical_condition": "Anxiety", "relationship": "therapeutic-dose", "evidence": "", "dose": "200-400 mg", "pmids": "31623400", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "l-theanine", "ingredient": "L-Theanine", "condition_id": "anxiety-stress", "condition": "Anxiety Stress", "canonical_condition_id": "anxiety", "canonical_condition": "Anxiety", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "31623400; 26797633", "source": "site-page", "source_url": "/l-theanine/for-anxiety-stress/" }, { "ingredient_id": "l-theanine", "ingredient": "L-Theanine", "condition_id": "sleep", "condition": "Sleep", "canonical_condition_id": "sleep", "canonical_condition": "Sleep", "relationship": "therapeutic-dose", "evidence": "", "dose": "200-400 mg", "pmids": "22214254", "source": "evidence-engine.clinical_doses", "source_url": "" }, { "ingredient_id": "l-theanine", "ingredient": "L-Theanine", "condition_id": "stress", "condition": "Stress", "canonical_condition_id": "stress", "canonical_condition": "Stress", "relationship": "reviewed-on-site", "evidence": "", "dose": "", "pmids": "23439798; 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